The association of subclinical infection with preterm labor: the role of C-reactive protein

Ronald K. Potkul; Atef H. Moawad; Kathryn L. Ponto

doi:10.1016/s0002-9378(85)80249-0

Pregnancy · Preterm Birth

The association of subclinical infection with preterm labor: the role of C-reactive protein

Potkul RK, Moawad AH, Ponto KL

Published November 15, 1985 American Journal of Obstetrics and Gynecology, 153(6), 642-645

DOI 10.1016/s0002-9378(85)80249-0 PMID 4061533

Abstract

The role of subclinical intrauterine infection in preterm labor was evaluated prospectively in 40 patients and appropriate control subjects. The 24 preterm labor patients (60%) with a negative C-reactive protein value responded to tocolysis 95.8% of the time, with a mean delay of delivery of 35.5 days and a mean gestational age of 36.9 weeks. The 16 patients (40%) with a positive C-reactive protein value responded to tocolysis only 37.5% of the time, with a mean delay of delivery of 14.4 days and a mean gestational age of 33.2 weeks. Pathologic evidence of chorioamnionitis was present in 32.9% of 310 preterm deliveries as compared to only 22.3% of 1631 term deliveries. The presence of subclinical infection must be considered in cases of preterm labor, especially among patients for whom tocolytic therapy is unsuccessful.

Topics

Pregnancy › Preterm Birth › Infection and Inflammation · Birth and Delivery › Labor and Birth › Physiologic Birth · General Gynecology › Infections › Vaginal and Cervical Infections

Ronald K. Potkul, Atef H. Moawad, Kathryn L. Ponto

Ron Potkul, R Potkul, A Moawad, Kathy Ponto, Kate Ponto, K Ponto

PMID 4061533 4061533 DOI 10.1016/s0002-9378(85)80249-0 10.1016/s0002-9378(85)80249-0 Potkul et al. 1985, Potkul 1985

Keywords

Adult, C-Reactive Protein, Chorioamnionitis/complications/diagnosis, Female, Gestational Age, Humans, Obstetric Labor, Premature/etiology, Pregnancy, Pregnancy Complications, Infectious/diagnosis, Prospective Studies, C-Reactive Protein

The association of subclinical infection with preterm labor: the role of C-reactive protein

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