The effect of oral micronized progesterone on hormonal and metabolic parameters in anovulatory patients with polycystic ovary syndrome

Sarantis Livadas; Georgios Boutzios; Fragiskos Economou; Krystallenia Alexandraki; Xenofon Xyrafis; Maria Christou; Aristea Zerva; Athanasios Karachalios; Evangelia Tantalaki; Evanthia Diamanti-Kandarakis

doi:10.1016/j.fertnstert.2009.02.073

Reproductive Endocrinology Ovarian Hormones

The effect of oral micronized progesterone on hormonal and metabolic parameters in anovulatory patients with polycystic ovary syndrome

Livadas S, Boutzios G, Economou F, Alexandraki K, Xyrafis X, Christou M, Zerva A, Karachalios A, Tantalaki E, Diamanti-Kandarakis E

Published June 2010 Fertility and sterility

DOI 10.1016/j.fertnstert.2009.02.073 PMID 19409554

Abstract

Objective

To investigate the effects of oral natural micronized P on hormonal and metabolic parameters in patients with polycystic ovary syndrome (PCOS) and to answer the clinical question whether induction of withdrawal bleeding is a necessity for the comparison of hormonal and metabolic data in subjects with PCOS.

Design

Prospective clinical study.

Setting

Academic medical center.

Patients

Twenty-eight reproductive-aged women with PCOS.

Main Outcome Measures

Blood sampling was collected at baseline, after 7 days of oral natural micronized P (200 mg) administration, and after withdrawal bleeding. At these three stages hormonal parameters and homeostasis assessment model (HOMA-IR) index were assessed in all patients.

Results

Oral natural micronized P administration did not alter significantly insulin sensitivity index and androgen levels; however, LH was decreased when postbleeding values were compared to baseline. Nevertheless, after oral natural micronized P administration, P and 17alpha-hydroxyprogesterone (17-OHP) concentrations were increased, and HOMA-IR was decreased, whereas androgens levels were not altered, in comparison with baseline.

Conclusions

The induction of withdrawal bleeding, with this regimen, does not appear to be a necessity for the assessment of hormonal and metabolic profile in anovulatory women with PCOS.

Topics

Reproductive Endocrinology › Ovarian Hormones › Progesterone · Menstrual Cycle › Cycle Disorders › Ovulatory Disturbances · Diagnostics › Hormone Testing › Timing of Testing

Sarantis Livadas, Georgios Boutzios, Fragiskos Economou, Krystallenia Alexandraki, Xenofon Xyrafis, Maria Christou, Aristea Zerva, Athanasios Karachalios, Evangelia Tantalaki, Evanthia Diamanti-Kandarakis

S Livadas, G Boutzios, F Economou, K Alexandraki, X Xyrafis, M Christou, A Zerva, A Karachalios, E Tantalaki, E Diamanti-Kandarakis

PMID 19409554 19409554 DOI 10.1016/j.fertnstert.2009.02.073 10.1016/j.fertnstert.2009.02.073 Livadas et al. 2010, Livadas 2010

The effect of oral micronized progesterone on hormonal and metabolic parameters in anovulatory patients with polycystic ovary syndrome

Abstract

Topics

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