Dalton, M. E. (1984). The effect of progesterone administration on sex hormone binding globulin binding capacity in women with severe premenstrual syndrome. Journal of Steroid Biochemistry, 20(1), 437-439. https://doi.org/10.1016/0022-4731(84)90249-8
Dalton ME. The effect of progesterone administration on sex hormone binding globulin binding capacity in women with severe premenstrual syndrome. J Steroid Biochem. 1984;20(1):437-439. doi:10.1016/0022-4731(84)90249-8
Dalton, Maureen E. "The effect of progesterone administration on sex hormone binding globulin binding capacity in women with severe premenstrual syndrome." Journal of Steroid Biochemistry, vol. 20, no. 1, 1984, pp. 437-439.
For EndNote, Zotero or Mendeley:
License
No open license is recorded for this paper. Reuse terms are set by the publisher.
Progesterone raised SHBG binding capacity in women with severe PMS
Progesterone raised SHBG binding capacity in women with severe premenstrual syndrome (PMS), a 1984 study of 31 volunteers with no comparison group. SHBG is a blood protein that carries sex hormones. In these women, levels were low at the start. They rose in all three dose groups, most in the highest.
Key Findings
Before treatment, the 31 women with severe PMS had low SHBG binding capacity.
SHBG binding capacity rose significantly in the 17 women in the lowest dose group (P < 0.01).
It also rose significantly in the 8 women in the middle dose group and the 6 women in the highest dose group (both P < 0.01).
Mean binding capacity was higher in each higher dose group: lowest, middle, then highest.
Women with more children and more severe symptoms usually started on higher doses and tended to have the lower pre-treatment binding capacities.
Interpretation
The study is a single-group before-and-after comparison from one Leeds hospital. Thirty-one volunteers served as their own comparison and the paper describes no placebo group, so the study cannot show that progesterone caused the rise. Dose groups were not randomized: women with more children and more severe symptoms usually started on higher doses. Blood was drawn once after seven days of treatment, so longer-term effects were not measured. The paper reports SHBG binding capacity and gives no symptom scores. The author proposes that progesterone influences SHBG at least indirectly. The mechanism of the rise is unknown.
RRM Context
Restorative reproductive medicine uses the charted cycle as evaluation data. The author diagnosed PMS by charting each woman's symptoms against her cycle. The discussion cites reports that SHBG binding capacity rises in the luteal phase after ovulation and falls after two synthetic progestins. Progesterone and progestins are different molecules.
Our editorial summary of this paper, not the article's abstract.
Abstract
Thirty-one women with severe premenstrual syndrome had low sex hormone binding globulin (SHBG) binding capacities 30.2 +/- 9.4 nmol DHT bound/l. The SHBG binding capacities rose when they were treated with three different doses of progesterone. On 400 mg (17 women) SHBG level was 45.11 +/- 11.80. On 800 mg (8 women) SHBG binding capacity rose to 64.75 +/- 14.30 and on the six women who took 1200 mg progesterone daily SHBG binding capacity was 78.5 +/- 23.10. These results are discussed.
01ge67z96 