Trends in copper versus hormonal intrauterine device breakage reporting within  the United States' Food and Drug Administration Adverse Event Reporting System

Kyle R Latack; Brian T Nguyen

doi:10.1016/j.contraception.2022.10.011

Contraception · Long Acting Methods

Trends in copper versus hormonal intrauterine device breakage reporting within the United States' Food and Drug Administration Adverse Event Reporting System

Latack KR, Nguyen BT

Published February 2023 Contraception, 118, 109909

DOI 10.1016/j.contraception.2022.10.011 PMID 36328095

Abstract

Objective

To examine trends in national reporting of broken intrauterine devices (IUDs).

Study Design

We enumerated IUD device "breakage" reports in the Food and Drug Administration Adverse Event Reporting System from inception (1998) until February 2022. We explored associations of breakage with IUD type (copper versus hormonal), year reported, reporter (consumer versus clinician), and patient characteristics (age and weight).

Results

We identified 4144 breakage reports for copper versus 2140 for hormonal IUDs. Among the 170,215 adverse events reported, breaks were disproportionately reported for copper (9.6%) versus hormonal (1.7%) IUDs.

Conclusion

National pharmacovigilance data suggests disproportionate breakage in copper versus hormonal IUDs though the true prevalence of breaks cannot be calculated from this dataset.

Topics

Contraception Long Acting Methods Intrauterine Devices

Contraception › Long Acting Methods › Intrauterine Devices

Kyle R Latack, Brian T Nguyen

K Latack, B Nguyen

PMID 36328095 36328095 DOI 10.1016/j.contraception.2022.10.011 10.1016/j.contraception.2022.10.011 Latack et al. 2023, Latack 2023

Keywords

Copper

Trends in copper versus hormonal intrauterine device breakage reporting within the United States' Food and Drug Administration Adverse Event Reporting System

Abstract

Topics

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