By RRM Academy Reviewed by Dr. Naomi Whittaker, MD, Board-Certified OBGYN, MIGS, NFPMC, FCI Updated May 31, 2026

D-Chiro-Inositol (DCI) is a secondary messenger in insulin signaling pathways that promotes cellular glucose uptake and reduces androgen synthesis. In PCOS, a defect in DCI metabolism (reduced conversion of myo-inositol to DCI) contributes to insulin resistance and hyperandrogenism.

DCI supplementation in PCOS reduces circulating androgen levels, improves insulin sensitivity, and can restore ovulatory function. However, high doses of DCI alone may negatively affect oocyte quality. The preferred clinical approach combines myo-inositol and DCI at a ratio approximating the physiological plasma proportion, rather than using DCI in isolation.

In RRM practice, ratio-based inositol supplementation is considered as a nutritional support option for women with PCOS, dosed under clinical supervision.

This content is for educational purposes only and does not constitute medical advice. Consult an RRM clinician or healthcare provider for guidance specific to your situation.