Myo-Inositol

By RRM Academy Reviewed by Dr. Naomi Whittaker, MD, Board-Certified OBGYN, MIGS, NFPMC, FCI Updated May 14, 2026

Myo-inositol is a naturally occurring carbocyclic sugar that functions as a secondary messenger in insulin signaling and follicle-stimulating hormone (FSH) pathways within ovarian tissue. Its role in reproductive physiology centers on insulin sensitization: disrupted inositol metabolism is a recognized feature of the insulin resistance seen across PCOS phenotypes, particularly Phenotypes A and B, where hyperandrogenism and metabolic dysfunction overlap.¹²

In women with PCOS, myo-inositol supplementation has been studied for its effects on menstrual cycle regularity, hormonal parameters, and ovarian function. Evidence supports improvements in LH-to-FSH ratios, reductions in androgen levels, and restoration of more regular ovulation in anovulatory patients.¹²

Myo-inositol has also been studied in the context of ovarian stimulation protocols, where it appears to support oocyte quality and metabolic markers.³ The available evidence base is strongest for metabolic and hormonal endpoints in PCOS; evidence for clinical pregnancy rate improvement is less consistent across studies, and no specific dose regimen is universally established.²

This content is for educational purposes only and does not constitute medical advice. Consult an RRM clinician or healthcare provider for guidance specific to your situation.