Myo-Inositol
Myo-inositol is a naturally occurring carbocyclic sugar that functions as a secondary messenger in insulin signaling and follicle-stimulating hormone (FSH) pathways within ovarian tissue. Its role in reproductive physiology centers on insulin sensitization: disrupted inositol metabolism is a recognized feature of the insulin resistance seen across PCOS phenotypes.1
In women with PCOS, researchers have studied myo-inositol supplementation for its effects on menstrual cycle regularity, hormonal parameters, and ovarian function. Evidence supports improvements in LH-to-FSH ratios, reductions in androgen levels, and restoration of more regular ovulation in anovulatory patients.1
Researchers have also studied myo-inositol in the context of ovarian stimulation protocols, where it appears to support oocyte quality and metabolic markers.2 The available evidence base is strongest for metabolic and hormonal endpoints in PCOS; evidence for clinical pregnancy rate improvement is less consistent across studies, and no specific dose regimen is universally established.1
Cited in this entry
- The Effectiveness of Myo-Inositol in Women With Polycystic Ovary Syndrome. https://pmc.ncbi.nlm.nih.gov/articles/PMC10926319/
- Effect of myo-inositol supplementation in mixed ovarian response. https://pmc.ncbi.nlm.nih.gov/articles/PMC11968372/
This content is for educational purposes only and does not constitute medical advice. Consult an RRM clinician or healthcare provider for guidance specific to your situation.