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Lisinopril

RRM Academy Dr. Naomi Whittaker, MD
By RRM Academy Reviewed by Dr. Naomi Whittaker, MD, Board-Certified OBGYN, MIGS, NFPMC, FCI

Lisinopril is a blood pressure pill that blocks an enzyme the body uses to narrow blood vessels. It also protects the kidneys in diabetes.

Lisinopril reaches fertility care through one small randomized crossover trial. The trial enrolled 33 men with normal blood pressure and a low sperm count of unknown cause. Sperm counts rose while the men took lisinopril and fell after they switched to placebo. Of the 28 men who finished, 15 improved overall.1

One pilot trial is a thin base, and lisinopril sits outside usual male factor care. It is an open question worth larger study.

Cited in this entry

  1. Mbah AU, Ndukwu GO, Ghasi SI, Shu EN, Ozoemena FN, Mbah JO, Onodugo OD, Ejim EC, Eze MI, Nkwo PO, Okonkwo PO. Low-dose lisinopril in normotensive men with idiopathic oligospermia and infertility: a 5-year randomized, controlled, crossover pilot study. Clinical Pharmacology and Therapeutics. 2012. Clinical Pharmacology and Therapeutics. https://pubmed.ncbi.nlm.nih.gov/22378155/

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