A cytogenetic study of 1000 spontaneous abortions

Hassold T; Chen N; Funkhouser J; Jooss T; Manuel B; Matsuura J; Matsuyama A; Wilson C; Yamane JA; Jacobs PA

doi:10.1111/j.1469-1809.1980.tb00955.x

Genetics and Immunology · Reproductive Genetics

A cytogenetic study of 1000 spontaneous abortions

Hassold T, Chen N, Funkhouser J, Jooss T, Manuel B, Matsuura J, Matsuyama A, Wilson C, Yamane JA, Jacobs PA

Published October 1980 Annals of Human Genetics, 44(2), 151-178

DOI 10.1111/j.1469-1809.1980.tb00955.x PMID 7316468

Abstract

Cytogenetic analysis of 1000 spontaneous abortions showed 463 to have an abnormal chromosome constitution. The proportion of chromosome abnormalities varied with the gestational age of the abortus and the type of tissue cultured but was not significantly different among the five racial groups represented in the study population. It was suggested that differences in the rate of chromosome abnormalities among cytogenetic studies of spontaneous abortions were the result of methodological differences in sample selection rather than real biological variation among study populations. The only factor found to be unequivocally associated with the aetiology of chromosome abnormalities in spontaneous abortions was increasing maternal age in trisomies.

Topics

Genetics and Immunology Reproductive Genetics Chromosomal Abnormalities

Genetics and Immunology › Reproductive Genetics › Chromosomal Abnormalities

PMID 7316468 7316468 DOI 10.1111/j.1469-1809.1980.tb00955.x 10.1111/j.1469-1809.1980.tb00955.x Hassold et al. 1980, Hassold 1980

Keywords

Abortion, Spontaneous/genetics, Cells, Cultured, Chromosome Aberrations, Ethnicity, Female, Gestational Age, Humans, Karyotyping, Male, Maternal Age, Paternal Age, Pregnancy, Sex Chromosome Aberrations, Sex Ratio, Trisomy

A cytogenetic study of 1000 spontaneous abortions

Abstract

Topics

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