Reproductive Endocrinology Luteal Phase

Clinical investigation of the menstrual cycle. II. Neuroendocrine investigation and therapy of the inadequate luteal phase

Gautray JP, Jolivet A, Goldenberg F, Tajchner G, Eberhard A

Published March 1978 Fertility and sterility
DOI 10.1016/s0015-0282(16)43152-3 PMID 640046

Abstract

Nonhormonal drugs--diphenylhydantoin and nialamide, which act on the central nervous system and have no known endocrine activity--were given to two groups of women with distinct types of electroencephalographic patterns in an effort to regulate menstrual disorders. Equalization of the lengths of both the follicular phase and the luteal phase to the normal range was observed during the drug therapy. Forty-five per cent of the pregnancy rate was achieved in 36 of the 80 infecund patients within 4 months of treatment. The mode of action of these drugs is still unknown.

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Reproductive Endocrinology › Luteal Phase › Luteal Phase Deficiency · Menstrual Cycle › Cycle Disorders › Ovulatory Disturbances · Infertility › Luteal Phase Defect › Diagnosis
PMID 640046 640046 DOI 10.1016/s0015-0282(16)43152-3 10.1016/s0015-0282(16)43152-3 Gautray et al. 1978, Gautray 1978