Luteal phase defects induced by an agonist of luteinizing hormone-releasing factor: a model for fertility control

Sheehan KL; Casper RF; Yen SS

doi:10.1126/science.6797068

Reproductive Endocrinology Luteal Phase

Luteal phase defects induced by an agonist of luteinizing hormone-releasing factor: a model for fertility control

Sheehan KL, Casper RF, Yen SS

Published January 8, 1982 Science (New York, N.Y.)

DOI 10.1126/science.6797068 PMID 6797068

Abstract

Subcutaneous injection of 50 micrograms of a luteinizing hormone-releasing factor agonist (LRF agonist) for three successive days at the time of menstruation in normal cycling women induces a shortened luteal phase with suboptimal concentrations of circulating estradiol and progesterone. This luteal phase defect follows a reduced concentration of follicle-stimulating hormone during the follicular phase and a resulting inadequate follicular maturation. Since a short luteal phase is associated with an endometrium not conductive to implantation, administration of the LRF agonist at the onset of menstrual cycle may prove to be a practical and novel approach to fertility control.

Topics

Reproductive Endocrinology › Luteal Phase › Luteal Phase Deficiency · Menstrual Cycle › Cycle Physiology › Luteal Phase · Therapeutics › Hormonal Agents › Gonadotropins

PMID 6797068 6797068 DOI 10.1126/science.6797068 10.1126/science.6797068 Sheehan et al. 1982, Sheehan 1982

Luteal phase defects induced by an agonist of luteinizing hormone-releasing factor: a model for fertility control

Abstract

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