Fertility and Sterility, 43(4), 514-519, 1985

Congenital malformations among offspring exposed in utero to progestins, Olmsted County, Minnesota, 1936-1974

W. Michael O’Fallon , J A Bruen , J F Hick

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DOI10.1016/s0015-0282(16)48490-6 PMID3987922
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Abstract

Comparison of a cohort of 988 offspring exposed in utero to exogenous progestins with a matched cohort of unexposed offspring did not result in detection of an association of congenital anomalies with exposure. The conclusions are based primarily on outcomes of pregnancy with exposure to progesterone and 17 alpha-hydroxyprogesterone caproate, and may not apply to androgenic progestins. Offspring exposed to combinations of progestins and estrogens were excluded from this study and may have a different distribution of anomalies.

Topics

in utero progestin exposure congenital malformations, progesterone pregnancy safety birth defects, 17 alpha-hydroxyprogesterone caproate fetal safety, progestin exposure offspring congenital anomalies cohort study, Resseguie progestin exposure Olmsted County, exogenous progesterone pregnancy teratogenicity, prenatal progestogen exposure birth outcomes, hydroxyprogesterone caproate safety pregnancy malformations, progestin versus androgenic progestin fetal effects, progesterone supplementation pregnancy fetal anomalies epidemiology
PMID 3987922 3987922 DOI 10.1016/s0015-0282(16)48490-6 10.1016/s0015-0282(16)48490-6

Cite this article

Resseguie, L. J., Hick, J. F., Bruen, J. A., Noller, K. L., O'Fallon, W. M., & Kurland, L. T. (1985). Congenital malformations among offspring exposed in utero to progestins, Olmsted County, Minnesota, 1936-1974. *Fertility and sterility*, *43*(4), 514-519. https://doi.org/10.1016/s0015-0282(16)48490-6

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