Congenital malformations among offspring exposed in utero to progestins, Olmsted County, Minnesota, 1936-1974

Laurence J. Resseguie; John F. Hick; Judith A. Bruen; Kenneth L. Noller; William M. O'Fallon; Leonard T. Kurland

doi:10.1016/s0015-0282(16)48490-6

Pregnancy · Fetal Medicine

Congenital malformations among offspring exposed in utero to progestins, Olmsted County, Minnesota, 1936-1974

Resseguie LJ, Hick JF, Bruen JA, Noller KL, O'Fallon WM, Kurland LT

Published April 1985 Fertility and Sterility, 43(4), 514-519

DOI 10.1016/s0015-0282(16)48490-6 PMID 3987922

Abstract

Comparison of a cohort of 988 offspring exposed in utero to exogenous progestins with a matched cohort of unexposed offspring did not result in detection of an association of congenital anomalies with exposure. The conclusions are based primarily on outcomes of pregnancy with exposure to progesterone and 17 alpha-hydroxyprogesterone caproate, and may not apply to androgenic progestins. Offspring exposed to combinations of progestins and estrogens were excluded from this study and may have a different distribution of anomalies.

Topics

Pregnancy Fetal Medicine Congenital Anomalies

Pregnancy › Fetal Medicine › Congenital Anomalies

Laurence J. Resseguie, John F. Hick, Judith A. Bruen, Kenneth L. Noller, William M. O'Fallon, Leonard T. Kurland

Larry Resseguie, L Resseguie, Jack Hick, J Hick, J Bruen, Ken Noller, K Noller, Bill O'Fallon, Will O'Fallon, Billy O'Fallon, W O'Fallon, L Kurland

PMID 3987922 3987922 DOI 10.1016/s0015-0282(16)48490-6 10.1016/s0015-0282(16)48490-6 Resseguie et al. 1985, Resseguie 1985

Keywords

17 alpha-Hydroxyprogesterone Caproate, Abnormalities, Drug-Induced/epidemiology, Ethisterone/adverse Effects, Female, Fetal Death/epidemiology, Humans, Hydroxyprogesterones/adverse Effects, Infant, Newborn, Male, Maternal-Fetal Exchange, Medroxyprogesterone/adverse Effects, Minnesota, Norethindrone/adverse Effects, Pregnancy, Prenatal Exposure Delayed Effects, Progesterone/adverse Effects, Progestins/adverse Effects, Hydroxyprogesterones, Progestins, 17 alpha-Hydroxyprogesterone Caproate, Progesterone, Medroxyprogesterone, Ethisterone, Norethindrone

Congenital malformations among offspring exposed in utero to progestins, Olmsted County, Minnesota, 1936-1974

Abstract

Topics

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Keywords