Prospective study of suspected associations between certain drugs administered during early pregnancy and congenital malformations

Michaelis J; Michaelis H; Glück E; Koller S

doi:10.1002/tera.1420270109

Pregnancy · Early Pregnancy

Prospective study of suspected associations between certain drugs administered during early pregnancy and congenital malformations

Michaelis J, Michaelis H, Glück E, Koller S

Published February 1983 Teratology, 27(1), 57-64

DOI 10.1002/tera.1420270109 PMID 6845218

Abstract

From 1964 to 1976, a cohort study was performed in West Germany to study the possible influence of various factors on pregnancy and child development. Results of the evaluation of 13,643 pregnancies are given with respect to possible teratogenetic effects of antiemetic drugs and sex hormones administered in early pregnancy. There was no evidence of an increased risk of major malformations following the intake of certain antiemetic drugs and progesterone. Also, the use of a hormonal pregnancy test was not significantly associated with an increase of major malformations.

Topics

Pregnancy Early Pregnancy Progesterone Support

Pregnancy › Early Pregnancy › Progesterone Support

PMID 6845218 6845218 DOI 10.1002/tera.1420270109 10.1002/tera.1420270109 Michaelis et al. 1983, Michaelis 1983

Keywords

Abnormalities, Drug-Induced/epidemiology, Antiemetics/adverse Effects, Dicyclomine, Doxylamine/adverse Effects, Drug Combinations/adverse Effects, Estradiol/adverse Effects/analogs & Derivatives, Female, Germany, West, Humans, Pregnancy, Progesterone/adverse Effects, Prospective Studies, Pyridoxine/adverse Effects, Time Factors, Antiemetics, Drug Combinations, Dicyclomine, Doxylamine, Pyridoxine Drug Combination, Progesterone, Dicyclomine, Estradiol, Estradiol Benzoate, Progesterone Drug Combination, Doxylamine, Pyridoxine

Prospective study of suspected associations between certain drugs administered during early pregnancy and congenital malformations

Abstract

Topics

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Keywords