Log normal distribution of gonadotropins and ovarian steroid values in the normal menstrual cycle

Kletzky OA; Nakamura RM; Thorneycroft IH; Mishell DR

doi:10.1016/0002-9378(75)90474-3

Menstrual Cycle Cycle Biomarkers

Log normal distribution of gonadotropins and ovarian steroid values in the normal menstrual cycle

Kletzky OA, Nakamura RM, Thorneycroft IH, Mishell DR

Published March 1975 American journal of obstetrics and gynecology

DOI 10.1016/0002-9378(75)90474-3 PMID 1115171

Abstract

In the statistical analysis of the values of luteinizing hormone, follicle-stimulating hormone, estradiol, and progesterone obtained from normal menstrual cycles, a depature from normality was noted. Chi square, W test, and linear transformation were used to check the normality of the distributions. The results of this investigation showed that the distributions were not normal (Gaussian) but log-normal. By plotting the probit of the percentages of cumulative frequency on a log scale (probit-log), linearity of the data was obtained. This resulted in direct graphical estimations of values with a useful clinical range, which included the mean and the 95 per cent confidence interval.

Topics

Menstrual Cycle › Cycle Biomarkers › Hormonal Markers · Reproductive Endocrinology › Ovarian Hormones › Estrogen · Research Methods › Measurement and Statistics › Statistical Methods

PMID 1115171 1115171 DOI 10.1016/0002-9378(75)90474-3 10.1016/0002-9378(75)90474-3 Kletzky et al. 1975, Kletzky 1975

Log normal distribution of gonadotropins and ovarian steroid values in the normal menstrual cycle

Abstract

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