Breast Cancer Research and Treatment, 120(1), 175-183, 2009
Oral contraceptives and postmenopausal hormones and risk of contralateral breast cancer among BRCA1 and BRCA2 mutation carriers and noncarriers: the WECARE Study
Jane C Figueiredo, Robert W Haile, Leslie Bernstein
Kathleen E Malone, Bryan Langholz, Charles F Lynch, Marinela Capanu, Patrick Concannon, Ake Borg, Børresen-Dale AL , Anne‐Lise Børresen‐Dale , Sharon N. Teraoka , Shanyan Xue, Jonine L Bernstein, Lisbeth Bertelsen , Anne-Lise Børresen-Dale , Anh Diep , Joan Largent , Therese Torngren
The potential effects of oral contraceptive (OC) and postmenopausal hormone (PMH) use are not well understood among BRCA1 or BRCA2 (BRCA1/2) deleterious mutation carriers with a history of breast cancer. We investigated the association between OC and PMH use and risk of contralateral breast cancer (CBC) in the WECARE (Women's Environment, Cancer, and Radiation Epidemiology) Study. The WECARE Study is a population-based case-control study of 705 women with asynchronous CBC and 1,398 women with unilateral breast cancer, including 181 BRCA1/2 mutation carriers. Risk-factor information was assessed by telephone interview. Mutation status was measured using denaturing high-performance liquid chromatography followed by direct sequencing in all participants. Outcomes, treatment, and tumor characteristics were abstracted from medical records. Ever use of OCs was not associated with risk among noncarriers (RR = 0.87; 95% CI = 0.66-1.15) or BRCA2 carriers (RR = 0.82; 95% CI = 0.21-3.13). BRCA1 carriers who used OCs had a nonsignificant greater risk than nonusers (RR = 2.38; 95% CI = 0.72-7.83). Total duration of OC use and at least 5 years of use before age 30 were associated with a nonsignificant increased risk among mutation carriers but not among noncarriers. Few women had ever used PMH and we found no significant associations between lifetime use and CBC risk among carriers and noncarriers. In conclusion, the association between OC/PMH use and risk of CBC does not differ significantly between carriers and noncarriers; however, because carriers have a higher baseline risk of second primaries, even a potential small increase in risk as a result of OC use may be clinically relevant.
BRCA1 BRCA2 breast cancer, oral contraceptive cancer risk, contralateral breast cancer, postmenopausal hormone therapy, WECARE study, mutation carrier contraception, hormone exposure breast cancer, bilateral breast cancer risk, genetic susceptibility hormones, case-control BRCA study
PMID 19597986 19597986 DOI 10.1007/s10549-009-0455-5 10.1007/s10549-009-0455-5
Cite this article
Figueiredo, J. C., Haile, R. W., Bernstein, L., Malone, K. E., Largent, J., Langholz, B., Lynch, C. F., Bertelsen, L., Capanu, M., Concannon, P., Borg, A., Børresen-Dale, A. L., Diep, A., Teraoka, S., Torngren, T., Xue, S., & Bernstein, J. L. (2010). Oral contraceptives and postmenopausal hormones and risk of contralateral breast cancer among BRCA1 and BRCA2 mutation carriers and noncarriers: the WECARE Study. Breast cancer research and treatment, 120(1), 175-183. https://doi.org/10.1007/s10549-009-0455-5
Figueiredo JC, Haile RW, Bernstein L, Malone KE, Largent J, Langholz B, et al. Oral contraceptives and postmenopausal hormones and risk of contralateral breast cancer among BRCA1 and BRCA2 mutation carriers and noncarriers: the WECARE Study. Breast Cancer Res Treat. 2010;120(1):175-183. doi:10.1007/s10549-009-0455-5
Figueiredo, J. C., et al. "Oral contraceptives and postmenopausal hormones and risk of contralateral breast cancer among BRCA1 and BRCA2 mutation carriers and noncarriers: the WECARE Study." Breast cancer research and treatment, vol. 120, no. 1, 2010, pp. 175-183.
Keywords
Contraceptives, Oral
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