Premenstrual syndrome: a double-blind controlled trial of progesterone and placebo

Gwyneth A. Sampson

doi:10.1192/bjp.135.3.209

Therapeutics · Hormonal Agents

Premenstrual syndrome: a double-blind controlled trial of progesterone and placebo

Sampson GA

Published September 1979 The British Journal of Psychiatry : the Journal of Mental Science, 135(3), 209-215

DOI 10.1192/bjp.135.3.209 PMID 385093

Abstract

Patients with premenstrual syndrome recorded their symptoms daily using menstrual distress questionnaires. These were analysed by a least mean square method of fitting sine waves. After recording an untreated cycle, patients were given progesterone 200 mg b.d. and placebo in a double-blind crossover manner; 75 per cent of patients were then given progesterone 400 mg b.d. and placebo in a similar manner. Treated cycles were rated by both daily menstrual distress questionnaires and retrospective self-assessment. Both rating methods showed there was no significant difference between progesterone and placebo in reducing symptoms of premenstrual syndrome, and in the majority of cases placebo was more effective, although never significantly so.

Topics

Therapeutics › Hormonal Agents › Progesterone and Progestins · Menstrual Cycle › Premenstrual Disorders › Premenstrual Syndrome Treatment · Reproductive Endocrinology › Ovarian Hormones › Progesterone

Gwyneth A. Sampson

G Sampson

PMID 385093 385093 DOI 10.1192/bjp.135.3.209 10.1192/bjp.135.3.209 Sampson et al. 1979, Sampson 1979

Keywords

Adult, Clinical Trials As Topic, Double-Blind Method, Female, Humans, Placebos, Premenstrual Syndrome/drug Therapy/psychology, Progesterone/therapeutic Use, Surveys and Questionnaires, Placebos, Progesterone

Premenstrual syndrome: a double-blind controlled trial of progesterone and placebo

Abstract

Topics

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Keywords