Pseudocorpus luteum insufficiency: a study of cytosol progesterone receptors in human endometrium

Spirtos NJ; Yurewicz EC; Moghissi KS; Magyar DM; Sundareson AS; Bottoms SF

Reproductive Endocrinology Luteal Phase

Pseudocorpus luteum insufficiency: a study of cytosol progesterone receptors in human endometrium

Spirtos NJ, Yurewicz EC, Moghissi KS, Magyar DM, Sundareson AS, Bottoms SF

Published April 1985 Obstetrics and gynecology

PMID 3982727

Abstract

This prospective, controlled study of 38 women was designed to compare the number of endometrial cytosol progesterone receptor (PRc) binding sites in infertile women with documented luteal phase defect with those of similar women without luteal phase defect. A 25% reduction in PRc binding sites was observed in women with luteal phase defect (P less than .05). Considerable overlap was noted between luteal phase defect and control groups; thus, no definite range of binding site numbers was predictive of luteal phase defect. The results of this study, therefore, suggest that an end-organ receptor defect may exist in some women with luteal phase abnormalities.

Topics

Reproductive Endocrinology › Luteal Phase › Luteal Phase Deficiency · Menstrual Cycle › Cycle Disorders › Ovulatory Disturbances · Diagnostics › Endometrial Assessment › Luteal Phase Biopsy

PMID 3982727 3982727 Spirtos et al. 1985, Spirtos 1985

Pseudocorpus luteum insufficiency: a study of cytosol progesterone receptors in human endometrium

Abstract

Topics

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