Clotting Cascade (Coagulation Cascade)
The clotting cascade is the chain of blood proteins that act in order to form a clot. Each protein switches on the next one. The chain seals an injury, then shuts itself down so the clot stays local.
Reproductive care meets this chain from two directions. Weak clotting shows up as heavy menstrual bleeding, and the FIGO system for abnormal uterine bleeding lists coagulopathy, a clotting problem, among the causes.1 Too much clotting sits behind thrombophilia, a clotting tendency, and antiphospholipid syndrome, which a recurrent pregnancy loss workup looks for.
One case report describes a woman treated for a suspected clotting problem along with her thyroid and glucose findings, plus progesterone timed to her charted cycle. She delivered a healthy baby at term.2
Cited in this entry
- Jain V, Munro MG, Critchley HOD. Contemporary evaluation of women and girls with abnormal uterine bleeding: FIGO Systems 1 and 2. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. 2023. https://pubmed.ncbi.nlm.nih.gov/37538019/
- Kicińska AM, Stachowska A, Kajdy A, Wierzba TH, Maksym RB. Successful Implementation of Menstrual Cycle Biomarkers in the Treatment of Infertility in Polycystic Ovary Syndrome-Case Report. Healthcare (Basel, Switzerland). 2023. https://pubmed.ncbi.nlm.nih.gov/36833150/
This content is for educational purposes only and does not constitute medical advice. Consult an RRM clinician or healthcare provider for guidance specific to your situation.
