Letrozole
Letrozole is an oral medicine used to bring on ovulation by lowering estrogen for a few days. The dip prompts the pituitary to release more FSH. A follicle then grows and opens.
At one center, 19.8 percent of cycles on letrozole alone gave a positive pregnancy test. Clomiphene alone gave 8 percent. Twin and higher pregnancies were less common with letrozole.1 Those cycles came from one clinic's records and were not randomized.
The restorative aim is to support a woman's own ovulation and keep her cycle intact. Letrozole was among the medicines most used in a cohort of 834 couples treated with natural procreative technology.2
Cited in this entry
- Mitwally MF, Casper RF. Aromatase inhibitors in ovulation induction. Seminars in Reproductive Medicine. 2004. https://pubmed.ncbi.nlm.nih.gov/15083382/
- Stanford JB, Parnell T, Kantor K, Reeder MR, Najmabadi S, Johnson K, Musso I, Hartman H, Tham E, Winter I, Galczynski K, Carus A, Sherlock A, Golden Tevald J, Barczentewicz M, Meier B, Carpentier PA, Poehailos K, Chasuk R, Lipscomb L, Danis PG. International Natural Procreative Technology Evaluation and Surveillance of Treatment for Subfertility (iNEST): enrollment and methods. Human Reproduction Open. 2022. https://pubmed.ncbi.nlm.nih.gov/35974874/
This content is for educational purposes only and does not constitute medical advice. Consult an RRM clinician or healthcare provider for guidance specific to your situation.
