Metformin

Metformin is a pill that lowers insulin resistance, so the body needs less insulin to move sugar into cells. It was built for type 2 diabetes and is widely used in PCOS (polycystic ovary syndrome, now also called PMOS).

High insulin pushes the ovary to make extra androgens, and that blocks ovulation. Lowering insulin can let ovulation return. One review pooled 13 randomized trials of 543 women with PCOS. Ovulation occurred in 46 of every 100 women on metformin, against 24 of every 100 on placebo.1

Metformin addresses one cause among several. Restorative care treats the insulin finding as one part of a larger picture.

Cited in this entry

  1. Lord JM, Flight IH, Norman RJ. Metformin in polycystic ovary syndrome: systematic review and meta-analysis. BMJ (Clinical Research Ed.). 2003. BMJ (Clinical Research Ed.). https://pubmed.ncbi.nlm.nih.gov/14576245/

This content is for educational purposes only and does not constitute medical advice. Consult an RRM clinician or healthcare provider for guidance specific to your situation.