Reproductive Endocrinology · Thyroid and Metabolic Function

Chapter 39: Medical Risks of Infertility

Hilgers TW

The Medical and Surgical Practice of NaProTECHNOLOGY, 495-508, 2004

RRM Academy Synopsis

Infertility is linked to diseases that carry long-term health risks

A 2004 textbook chapter says infertility is a symptom of an underlying disease. It associates those diseases with higher risks of some cancers, diabetes and bone loss. The author also covers PCOS and risks in later pregnancies.

Key Findings

  • The chapter states that progesterone production after ovulation is significantly decreased in women with endometriosis, polycystic ovarian disease, pelvic adhesive disease and tubal occlusion.
  • Studies cited in the chapter suggest women with polycystic ovarian disease face higher risks of type 2 diabetes, high blood pressure, abnormal blood fats and heart attack.
  • The chapter cites work associating endometriosis with ovarian and breast cancer, and long-term lack of ovulation with endometrial cancer. It calls some links well established and others speculative.
  • Studies cited in the chapter report higher risks of miscarriage, ectopic pregnancy, stillbirth, pregnancy-induced hypertension, preterm delivery and low birth weight in later pregnancies after infertility.
  • A cost study the chapter cites estimated an added $0.67 per member per month for infertility evaluation and treatment programs in a health plan.

RRM Context

The chapter treats infertility as a symptom to trace to a cause. RRM shares that principle. Evaluation comes before treatment, and both partners are evaluated. Unexplained infertility is undiagnosed. The chapter lists laparoscopy, ultrasound, hormone testing, tubal testing and semen analysis as tools that also serve women's health.

Abstract

This chapter describes infertility as associated with diseases that affect both a woman's fertility and her general health, a pattern the author calls a "two-pronged" effect. The chapter reviews reported associations between conditions such as endometriosis, polycystic ovarian disease and pelvic adhesive disease and pelvic pain, bowel symptoms, metabolic disturbance, ovarian, endometrial and breast cancer, osteoporosis, immune alterations and complications in later pregnancies. Hilgers presents Pope Paul VI Institute data showing lower post-Peak progesterone levels in women with infertility and regular cycles than in controls, and higher androgen levels in women with polycystic ovarian disease. The chapter criticizes insurance exclusions of "fertility-related services" as unevenly applied and as targeting women, and cites a study estimating the added cost of infertility evaluation and treatment at $0.67 per member per month.

Topics

By this author

Related research

Reproductive Endocrinology › Thyroid and Metabolic Function › Thyroid Disorders · General Gynecology › Screening and Prevention › Metabolic and Cardiovascular Screening
Thomas W Hilgers
Tom Hilgers, T Hilgers
Hilgers et al. 2004, Hilgers 2004