Cognitive decline is associated with an accelerated rate of bone loss and  increased fracture risk in women: a prospective study from the Canadian  Multicentre Osteoporosis Study

Bliuc D; Tran T; Adachi JD; Atkins GJ; Berger C; van den Bergh J; Cappai R; Eisman JA; van Geel T; Geusens P; Goltzman D; Hanley DA; Josse R; Kaiser S; Kovacs CS; Langsetmo L; Prior JC; Nguyen TV; Solomon LB; Stapledon C; Center JR; Canadian Multicentre Osteoporosis Study (CaMos) Research Group

doi:10.1002/jbmr.4402

Bone Health · Osteoporosis

Cognitive decline is associated with an accelerated rate of bone loss and increased fracture risk in women: a prospective study from the Canadian Multicentre Osteoporosis Study

Bliuc D, Tran T, Adachi JD, Atkins GJ, Berger C, van den Bergh J, Cappai R, Eisman JA, van Geel T, Geusens P, Goltzman D, Hanley DA, Josse R, Kaiser S, Kovacs CS, Langsetmo L, Prior JC, Nguyen TV, Solomon LB, Stapledon C, Center JR, Canadian Multicentre Osteoporosis Study (CaMos) Research Group

Published November 2021 Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 36(11), 2106-2115

DOI 10.1002/jbmr.4402 PMID 34289172

Abstract

Cognitive decline and osteoporosis often coexist and some evidence suggests a causal link. However, there are no data on the longitudinal relationship between cognitive decline, bone loss and fracture risk, independent of aging. This study aimed to determine the association between: (i) cognitive decline and bone loss; and (ii) clinically significant cognitive decline (≥3 points) on Mini Mental State Examination (MMSE) over the first 5 years and subsequent fracture risk over the following 10 years. A total of 1741 women and 620 men aged ≥65 years from the population-based Canadian Multicentre Osteoporosis Study were followed from 1997 to 2013. Association between cognitive decline and (i) bone loss was estimated using mixed-effects models; and (ii) fracture risk was estimated using adjusted Cox models. Over 95% of participants had normal cognition at baseline (MMSE ≥ 24). The annual % change in MMSE was similar for both genders (women -0.33, interquartile range [IQR] -0.70 to +0.00; and men -0.34, IQR: -0.99 to 0.01). After multivariable adjustment, cognitive decline was associated with bone loss in women (6.5%; 95% confidence interval [CI], 3.2% to 9.9% for each percent decline in MMSE from baseline) but not men. Approximately 13% of participants experienced significant cognitive decline by year 5. In women, fracture risk was increased significantly (multivariable hazard ratio [HR], 1.61; 95% CI, 1.11 to 2.34). There were too few men to analyze. There was a significant association between cognitive decline and both bone loss and fracture risk, independent of aging, in women. Further studies are needed to determine mechanisms that link these common conditions.

Responses

Bone Mineral Density · Measurement

Reply to: The Association Between Cognitive Decline and Bone Loss and Fracture Risk Is Not Affected by Medication With Anticholinergic Effect

Bliuc D et al., 2022

Topics

Bone Health Osteoporosis Diagnosis and Treatment

Bone Health › Osteoporosis › Diagnosis and Treatment

Gerald J Atkins, Roberto Cappai, Lucian B Solomon, Jerilynn C Prior

G Atkins, R Cappai, L Solomon, J Prior

PMID 34289172 34289172 DOI 10.1002/jbmr.4402 10.1002/jbmr.4402 Bliuc et al. 2021, Bliuc 2021

Cognitive decline is associated with an accelerated rate of bone loss and increased fracture risk in women: a prospective study from the Canadian Multicentre Osteoporosis Study

Abstract

Responses

Topics

By this author

Related research