Differences in fracture prevalence and in bone mineral density between Chinese and White Canadians: the Canadian Multicentre Osteoporosis Study (CaMos)

S N Morin, C Berger, W Liu, J C Prior, A M Cheung, D A Hanley, S K Boyd, A K O Wong, A Papaioannou, E Rahme, D Goltzman

doi:10.1007/s11657-020-00822-4

Arch Osteoporos, 15(1), 147, 2020

Differences in fracture prevalence and in bone mineral density between Chinese and White Canadians: the Canadian Multicentre Osteoporosis Study (CaMos)

Alexandra Papaioannou , Elham Rahme , A K O Wong

Author affiliations (8)

McMaster University, Hamilton, ON, Canada ROR
McGill University Health Centre ROR
Public Health Ontario ROR
Department of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
Department of Medicine and Joint Department of Medical Imaging, Centre of Excellence in Skeletal Health Assessment, University Health NetworkUniversity of TorontoTorontoONCanada ROR
Department of Medicine, University of Calgary, Calgary, Alberta, Canada. ROR
McGill University ROR
Vancouver Hospital and Health Sciences Centre ROR

DOI10.1007/s11657-020-00822-4 PMID32955674

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Abstract

Fracture determinants differ between Canadians of Chinese and White descent, the former constituting the second largest visible minority group in Canada. The results of this study support the importance of characterizing bone health predictors in Canadians of different ethnicity to improve population-specific fracture prevention and treatment strategies.

Purpose

We aimed to compare clinical risk factors, bone mineral density, prevalence of osteoporosis, and fractures between Chinese and White Canadians to identify ethnicity-specific risks.

Methods

We studied 236 Chinese and 8945 White Canadians aged 25+ years from the Canadian Multicentre Osteoporosis Study (CaMos). The prevalence of osteoporosis using ethnicity-specific peak bone mass (PBM), and of prior and incident low trauma fractures were assessed and compared between groups. Linear regressions, adjusting for age and anthropometric measures, were used to examine the association between baseline and 5-year changes in BMD and ethnicity.

Results

Chinese participants had shorter stature, lower BMI, and lower rate of falls than White participants. Adjusted models showed no significant differences in baseline BMD between ethnic groups except in younger men where total hip BMD was 0.059 g/cm2 (0.009; 0.108) lower in Chinese. Adjusted 5-year BMD change at lumbar spine was higher in older Chinese women and men compared with Whites. When using Chinese-specific PBM, the prevalence of osteoporosis in Chinese women was 2-fold lower than when using that of White women The prevalence of fractures was higher in White women compared with Chinese with differences up to 14.5% (95% CI 9.2; 19.7) and 10.5% (95% CI 4.5-16.4) in older White men. Incident fractures were rare in young Chinese compared with White participants and not different in the older groups.

Conclusion

Our results support the importance of characterizing bone strength predictors in Chinese Canadians and the development of ethnicity-specific fracture prediction and prevention strategies.

Topics

Bone Health > Osteoporosis > Ethnic Differences in Bone Density Reproductive Endocrinology > Bone Metabolism > Population-Based Studies Research Methodology > Cohort Studies > Multicentre Observational

bone mineral density ethnic differences Chinese White Canadians, Prior JC CaMos osteoporosis ethnicity fracture risk, Canadian Multicentre Osteoporosis Study ethnic bone health, ethnicity-specific peak bone mass fracture prevalence, Chinese Canadian osteoporosis prevalence comparison, total hip BMD ethnic differences men women, fracture prediction ethnicity-specific strategies, lumbar spine BMD change longitudinal ethnic comparison, population-based cohort osteoporosis ethnic minority, low trauma fracture incidence Chinese versus White

PMID 32955674 32955674 DOI 10.1007/s11657-020-00822-4 10.1007/s11657-020-00822-4

Cite this article

Morin, S. N., Berger, C., Liu, W., Prior, J. C., Cheung, A. M., Hanley, D. A., Boyd, S. K., Wong, A. K. O., Papaioannou, A., Rahme, E., Goltzman, D., & CaMos Research Group (2020). Differences in fracture prevalence and in bone mineral density between Chinese and White Canadians: the Canadian Multicentre Osteoporosis Study (CaMos). *Archives of osteoporosis*, *15*(1), 147. https://doi.org/10.1007/s11657-020-00822-4

Differences in fracture prevalence and in bone mineral density between Chinese and White Canadians: the Canadian Multicentre Osteoporosis Study (CaMos)

Abstract

Topics

Cite this article

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