Prior oral contraception and postmenopausal fracture: a Women's Health Initiative  observational cohort study

David Barad; Charles Kooperberg; Jean Wactawski-Wende; James Liu; Susan L Hendrix; Nelson B Watts

doi:10.1016/j.fertnstert.2005.01.132

Bone Health · Fracture Risk

Prior oral contraception and postmenopausal fracture: a Women's Health Initiative observational cohort study

Barad D, Kooperberg C, Wactawski-Wende J, Liu J, Hendrix SL, Watts NB

Published August 9, 2005 Fertility and Sterility, 84(2), 374-383

DOI 10.1016/j.fertnstert.2005.01.132 PMID 16084878

Abstract

Objective

To test for the possible association of past oral contraceptive (OC) use and incident fracture after menopause.

Design

A prospective cohort of 93,725 postmenopausal women.

Setting

Forty Women's Health Initiative (WHI) clinical centers across the United States.

Patients

Ethnically diverse 93,725 volunteer postmenopausal women, 50 to 79 years old.

Interventions

None.

Main Outcome Measures

The main outcome was self-reported incident first fracture assessed prospectively by annual questionnaire.

Results

The adjusted relative hazard (HR) for fracture among past OC users was 1.07 (95% CI, 1.01-1.15). Among women without any postmenopausal hormone treatment, past OC use for < or =5 years led to an HR of 1.15 (95% CI, 1.04-1.27) and for past OC use >5 years led to an HR of 1.09 (95% CI, 0.97-1.23) compared with never users.

Conclusions

This study does not support the idea that past OC use protects against later fracture.

Topics

Bone Health › Fracture Risk › Risk Factors · Contraception › Oral Contraceptives › Metabolic Effects · Perimenopause and Menopause › Long Term Health › Bone Loss

David Barad, Charles Kooperberg, Jean Wactawski-Wende, James Liu, Susan L Hendrix, Nelson B Watts

Dave Barad, D Barad, Charlie Kooperberg, Chuck Kooperberg, C Kooperberg, J Wactawski-Wende, Jim Liu, Jimmy Liu, J Liu, Sue Hendrix, S Hendrix, N Watts

PMID 16084878 16084878 DOI 10.1016/j.fertnstert.2005.01.132 10.1016/j.fertnstert.2005.01.132 Barad et al. 2005, Barad 2005

Keywords

Contraceptives, Oral

Prior oral contraception and postmenopausal fracture: a Women's Health Initiative observational cohort study

Abstract

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