Normative bone mineral density z-scores for Canadians aged 16 to 24 years: the  Canadian Multicenter Osteoporosis Study

Wei Zhou; Lisa Langsetmo; Claudie Berger; Jonathan D Adachi; Alexandra Papaioannou; George Ioannidis; Colin Webber; Stephanie A Atkinson; Wojciech P Olszynski; Jacques P Brown; David A Hanley; Robert Josse; Nancy Kreiger; Jerilynn Prior; Stephanie Kaiser; Susan Kirkland; David Goltzman; Kenneth Shawn Davison; CaMos Research Group

doi:10.1016/j.jocd.2010.04.005

Bone Health · Bone Mineral Density

Normative bone mineral density z-scores for Canadians aged 16 to 24 years: the Canadian Multicenter Osteoporosis Study

Zhou W, Langsetmo L, Berger C, Adachi JD, Papaioannou A, Ioannidis G, Webber C, Atkinson SA, Olszynski WP, Brown JP, Hanley DA, Josse R, Kreiger N, Prior J, Kaiser S, Kirkland S, Goltzman D, Davison KS, CaMos Research Group

Published June 18, 2010 Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry, 13(3), 267-276

DOI 10.1016/j.jocd.2010.04.005 PMID 20554232 PMC PMC5104562

Abstract

The objectives of the study were to develop bone mineral density (BMD) reference norms and BMD Z-scores at various skeletal sites, to determine whether prior fracture and/or asthma were related to BMD, and to assess possible geographic variation of BMD among Canadian youth aged 16-24 yr. Z-Scores were defined as the number of standard deviations from the mean BMD of a healthy population of the same age, race, and sex. Z-Scores were calculated using the reference sample defined as Canadian Caucasian participants without asthma or prior fracture. Reference standards were created for lumbar spine (L1-L4), femoral neck, total hip, and greater trochanter, by each year of age (16-24 yr), and by sex. The Z-score norms were developed for groups noted earlier. Mean Z-scores between the asthma or fracture subgroups compared with the mean Z-scores in the reference sample were not different. There were minor differences in mean BMD across different Canadian geographic regions. This study provides age, sex, and skeletal site-specific Caucasian reference norms and formulae for the calculation of BMD Z-scores for Canadian youth aged 16-24 yr. This information will be valuable to help to identify individuals with clinically meaningful low BMD.

Topics

Bone Health › Bone Mineral Density › Peak Bone Mass · Research Methods › Measurement and Statistics › Outcome Definitions

Wei Zhou, Lisa Langsetmo, Claudie Berger, Jonathan D Adachi, Alexandra Papaioannou, George Ioannidis, Colin Webber, Stephanie A Atkinson, Wojciech P Olszynski, Jacques P Brown, David A Hanley, Robert Josse, Nancy Kreiger, Jerilynn Prior, Stephanie Kaiser, Susan Kirkland, David Goltzman, Kenneth Shawn Davison

W Zhou, L Langsetmo, C Berger, Jon Adachi, J Adachi, Alex Papaioannou, A Papaioannou, G Ioannidis, C Webber, S Atkinson, W Olszynski, J Brown, Dave Hanley, D Hanley, Bob Josse, Rob Josse, Bobby Josse, R Josse, N Kreiger, J Prior, S Kaiser, Sue Kirkland, S Kirkland, Dave Goltzman, D Goltzman, Ken Davison, K Davison

PMID 20554232 20554232 DOI 10.1016/j.jocd.2010.04.005 10.1016/j.jocd.2010.04.005 Zhou et al. 2010, Zhou 2010

Normative bone mineral density z-scores for Canadians aged 16 to 24 years: the Canadian Multicenter Osteoporosis Study

Abstract

Topics

By this author

Related research