Q-IVF, & National Quality Registry for Assisted Reproduction (2020). Q-IVF Annual Report 2020: Fertility Treatments in Sweden (Treatment Year 2018). Q-IVF.
Q-IVF, National Quality Registry for Assisted Reproduction. Q-IVF Annual Report 2020: Fertility Treatments in Sweden (Treatment Year 2018). Q-IVF; 2020.
Q-IVF, and National Quality Registry for Assisted Reproduction. Q-IVF Annual Report 2020: Fertility Treatments in Sweden (Treatment Year 2018). Q-IVF, 2020.
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RRM Academy Synopsis
About 20% of Swedish fresh IVF cycles with own gametes ended in birth
Sweden's national IVF registry reports that about 20% of fresh IVF cycles started in 2018 with the couple's own gametes ended in a live birth, 2 255 of 11 061 cycles at eighteen clinics. The annual report also presents frozen embryo cycles, twin deliveries and complications.
Key Findings
Of 11 061 fresh IVF cycles started with the couple's own gametes, 8 066 reached embryo transfer and 2 255 resulted in live births, about 20%.
The report names the woman's age as the most important factor in the chance of a live birth with her own oocytes, because oocyte numbers and quality decrease at a higher age.
Frozen embryo cycles (7 041 started, 6 787 with embryo transfer) resulted in 2 273 deliveries; the report associates improved results with extended culture to the blastocyst stage.
Twins made up 2.54% of deliveries and there were no triplet deliveries; the report attributes the low multiple pregnancy rate to transferring one embryo at a time in most cycles.
Complications went unreported in 15% of fresh cycles; those reported included 42 cases of ovarian hyperstimulation syndrome requiring hospitalization, nine cases of bleeding and 11 cases of infection.
Interpretation
The report compiles aggregated registry counts for cycles started in 2018, with almost 100% of Swedish IVF cycles accounted for. The counts describe outcomes after IVF and include no comparison group of couples who did not undergo it. Some started cycles were not intended for embryo transfer, such as freezing eggs or embryos before chemotherapy, and the registry's authors state that live births per started cycle alone can mislead. The authors also note that clinics treat patients of different ages.
RRM Context
IVF bypasses the reproductive system and leaves the cause of infertility in place. Live births per cycle show how often the bypass ends in a birth. The report attributes infertility about equally to the man, the woman, or both partners. It notes that some cases have no explanation and calls them unexplained infertility. Restorative reproductive medicine evaluates both partners to find the cause and regards unexplained infertility as undiagnosed.
Our editorial summary of this paper, not the article's abstract.
Key figures
Registry overview, 2018
Measure
Value
Source
IVF clinics reporting to Q-IVF registry, 2018
18
Notes from head of registry
Publicly run IVF clinics, 2018
6
Notes from head of registry
Privately run IVF clinics, 2018
12
Notes from head of registry
Clinic reporting coverage to the Q-IVF registry, 2018
near 100%
Notes from head of registry
Cumulative assisted-reproduction treatments logged in Q-IVF, as of 2018
just over 240 000
How we collect data section
IVF treatment volume, own gametes, 2018
Measure
Value
Source
IVF treatment cycles started with own gametes, 2018 (total)
18,102
Table 1
Fresh IVF/ICSI cycles started with own gametes, 2018
11,061
Table 1
Frozen embryo transfer (freeze) cycles started with own gametes, 2018
7,041
Table 1
Deliveries, own gametes, 2018
Measure
Value
Source
Deliveries from IVF with own gametes, 2018 (total)
4,528
Table 1
Deliveries from fresh IVF cycles with own gametes, 2018
2,255
Table 1
Deliveries from freeze cycles with own gametes, 2018
2,273
Table 1
Live births by cycle type, 2018
Measure
Value
Source
Live births from freeze cycles, all treatment types including donated gametes, 2018
2,524
Figure 19
Live births from fresh IVF cycles, all treatment types including donated gametes, 2018
2,522
Figure 19
Live births summary, 2018
Measure
Value
Source
Children born as a result of IVF, 2018
5,043
Report text
Total children born through assisted reproduction (IVF plus donor insemination), 2018
5,386
Report text
Donor insemination (AID), 2018
Measure
Value
Source
Donor insemination (AID) cycles started, 2018
2,237
Table 8 and Figure 24
Deliveries from donor insemination cycles, 2018
340
Table 8 and Figure 24
Children born through donor insemination, 2018
343
Table 8 and Figure 24
Delivery rate per insemination, donor insemination, 2018
14.5%
Table 8 and Figure 24
IVF live birth rates, own gametes, 2018
Measure
Value
Source
Live birth rate per started cycle, fresh IVF, all ages, 2018
20.4%
Figure 13
Live birth rate per embryo transfer, fresh IVF, all ages, 2018
28.0%
Figure 14
Live birth rate per embryo transfer, fresh IVF, women under 30, 2018
38.8%
Figure 14
Live birth rate per embryo transfer, fresh IVF, women aged 40-41, 2018
12.9%
Figure 14
Live birth rate per embryo transfer, fresh IVF, women aged 42 and older, 2018
9.3%
Figure 14
Live birth rate per embryo transfer, freeze cycles, all ages, 2018
33.5%
Figure 14
IVF with donated gametes, 2018
Measure
Value
Source
Live birth rate per embryo transfer, donated oocytes, fresh cycles, 2018
36.3%
Figure 21
Live birth rate per embryo transfer, donated oocytes, freeze cycles, 2018
24.2%
Figure 21
Chance of a child per fresh treatment, own oocytes with donated sperm, 2018
about 30%
IVF with donated gametes section
Patients with a baby per fresh donated-oocyte treatment, 2018
about 35%
IVF with donated oocytes section
PGT cycles, 2018
Measure
Value
Source
PGT cycles started, 2018
330
Figure 8
Embryo transfers from PGT cycles, 2018
262
Figure 8
Clinical pregnancies from PGT cycles, 2018
93
Figure 8
Deliveries from PGT cycles, 2018
83
Figure 8
Cumulative babies born from a process involving PGT, as of 2018
nearly 500
PGT section
Fertility preservation (oocyte freezing), 2018
Measure
Value
Source
Oocyte freezing cycles performed, 2018 (total)
448
Figures 25-26
Oocyte freezing cycles for an oncologic indication, 2018
139
Figures 25-26
Oocyte freezing cycles for non-medical (social) reasons, 2018
283
Figures 25-26
Oocyte freezing cycles for other medical reasons, 2018
26
Figures 25-26
Embryo transfer practice, 2018
Measure
Value
Source
Single embryo transfer rate, fresh IVF cycles, 2007 to 2018
69.6% to 86.7%
Figure 10a
Single embryo transfer rate, freeze cycles, 2018
98.2%
Figure 10b
Freeze cycles using embryos cultured to day 5-6 (blastocyst), 2018
90%
Embryo culture duration section
Multiple births, 2018
Measure
Value
Source
Multiple birth rate per delivery, IVF with own gametes, 2018 (all cycle types)
2.54%
Table 4
Multiple birth rate per delivery, fresh IVF cycles with own gametes, 2018
2.70%
Table 4
Multiple birth rate per delivery, freeze cycles with own gametes, 2018
2.37%
Table 4
Multiple pregnancy rate in other countries (context, not Sweden's own figure)
25%-30%
Multiple pregnancy section
Multiple pregnancy rate for spontaneous conception (context, not Sweden's own figure)