RRM Academy Synopsis
About 20% of Swedish fresh IVF cycles with own gametes ended in birth
Sweden's national IVF registry reports that about 20% of fresh IVF cycles started in 2018 with the couple's own gametes ended in a live birth, 2 255 of 11 061 cycles at eighteen clinics. The annual report also presents frozen embryo cycles, twin deliveries and complications.
Key Findings
- Of 11 061 fresh IVF cycles started with the couple's own gametes, 8 066 reached embryo transfer and 2 255 resulted in live births, about 20%.
- The report names the woman's age as the most important factor in the chance of a live birth with her own oocytes, because oocyte numbers and quality decrease at a higher age.
- Frozen embryo cycles (7 041 started, 6 787 with embryo transfer) resulted in 2 273 deliveries; the report associates improved results with extended culture to the blastocyst stage.
- Twins made up 2.54% of deliveries and there were no triplet deliveries; the report attributes the low multiple pregnancy rate to transferring one embryo at a time in most cycles.
- Complications went unreported in 15% of fresh cycles; those reported included 42 cases of ovarian hyperstimulation syndrome requiring hospitalization, nine cases of bleeding and 11 cases of infection.
Interpretation
The report compiles aggregated registry counts for cycles started in 2018, with almost 100% of Swedish IVF cycles accounted for. The counts describe outcomes after IVF and include no comparison group of couples who did not undergo it. Some started cycles were not intended for embryo transfer, such as freezing eggs or embryos before chemotherapy, and the registry's authors state that live births per started cycle alone can mislead. The authors also note that clinics treat patients of different ages.
RRM Context
IVF bypasses the reproductive system and leaves the cause of infertility in place. Live births per cycle show how often the bypass ends in a birth. The report attributes infertility about equally to the man, the woman, or both partners. It notes that some cases have no explanation and calls them unexplained infertility. Restorative reproductive medicine evaluates both partners to find the cause and regards unexplained infertility as undiagnosed.
Key figures
Registry overview, 2018
| Measure | Value | Source |
|---|---|---|
| IVF clinics reporting to Q-IVF registry, 2018 | 18 | Notes from head of registry |
| Publicly run IVF clinics, 2018 | 6 | Notes from head of registry |
| Privately run IVF clinics, 2018 | 12 | Notes from head of registry |
| Clinic reporting coverage to the Q-IVF registry, 2018 | near 100% | Notes from head of registry |
| Cumulative assisted-reproduction treatments logged in Q-IVF, as of 2018 | just over 240 000 | How we collect data section |
IVF treatment volume, own gametes, 2018
| Measure | Value | Source |
|---|---|---|
| IVF treatment cycles started with own gametes, 2018 (total) | 18,102 | Table 1 |
| Fresh IVF/ICSI cycles started with own gametes, 2018 | 11,061 | Table 1 |
| Frozen embryo transfer (freeze) cycles started with own gametes, 2018 | 7,041 | Table 1 |
Deliveries, own gametes, 2018
| Measure | Value | Source |
|---|---|---|
| Deliveries from IVF with own gametes, 2018 (total) | 4,528 | Table 1 |
| Deliveries from fresh IVF cycles with own gametes, 2018 | 2,255 | Table 1 |
| Deliveries from freeze cycles with own gametes, 2018 | 2,273 | Table 1 |
Live births by cycle type, 2018
| Measure | Value | Source |
|---|---|---|
| Live births from freeze cycles, all treatment types including donated gametes, 2018 | 2,524 | Figure 19 |
| Live births from fresh IVF cycles, all treatment types including donated gametes, 2018 | 2,522 | Figure 19 |
Live births summary, 2018
| Measure | Value | Source |
|---|---|---|
| Children born as a result of IVF, 2018 | 5,043 | Report text |
| Total children born through assisted reproduction (IVF plus donor insemination), 2018 | 5,386 | Report text |
Donor insemination (AID), 2018
| Measure | Value | Source |
|---|---|---|
| Donor insemination (AID) cycles started, 2018 | 2,237 | Table 8 and Figure 24 |
| Deliveries from donor insemination cycles, 2018 | 340 | Table 8 and Figure 24 |
| Children born through donor insemination, 2018 | 343 | Table 8 and Figure 24 |
| Delivery rate per insemination, donor insemination, 2018 | 14.5% | Table 8 and Figure 24 |
IVF live birth rates, own gametes, 2018
| Measure | Value | Source |
|---|---|---|
| Live birth rate per started cycle, fresh IVF, all ages, 2018 | 20.4% | Figure 13 |
| Live birth rate per embryo transfer, fresh IVF, all ages, 2018 | 28.0% | Figure 14 |
| Live birth rate per embryo transfer, fresh IVF, women under 30, 2018 | 38.8% | Figure 14 |
| Live birth rate per embryo transfer, fresh IVF, women aged 40-41, 2018 | 12.9% | Figure 14 |
| Live birth rate per embryo transfer, fresh IVF, women aged 42 and older, 2018 | 9.3% | Figure 14 |
| Live birth rate per embryo transfer, freeze cycles, all ages, 2018 | 33.5% | Figure 14 |
IVF with donated gametes, 2018
| Measure | Value | Source |
|---|---|---|
| Live birth rate per embryo transfer, donated oocytes, fresh cycles, 2018 | 36.3% | Figure 21 |
| Live birth rate per embryo transfer, donated oocytes, freeze cycles, 2018 | 24.2% | Figure 21 |
| Chance of a child per fresh treatment, own oocytes with donated sperm, 2018 | about 30% | IVF with donated gametes section |
| Patients with a baby per fresh donated-oocyte treatment, 2018 | about 35% | IVF with donated oocytes section |
PGT cycles, 2018
| Measure | Value | Source |
|---|---|---|
| PGT cycles started, 2018 | 330 | Figure 8 |
| Embryo transfers from PGT cycles, 2018 | 262 | Figure 8 |
| Clinical pregnancies from PGT cycles, 2018 | 93 | Figure 8 |
| Deliveries from PGT cycles, 2018 | 83 | Figure 8 |
| Cumulative babies born from a process involving PGT, as of 2018 | nearly 500 | PGT section |
Fertility preservation (oocyte freezing), 2018
| Measure | Value | Source |
|---|---|---|
| Oocyte freezing cycles performed, 2018 (total) | 448 | Figures 25-26 |
| Oocyte freezing cycles for an oncologic indication, 2018 | 139 | Figures 25-26 |
| Oocyte freezing cycles for non-medical (social) reasons, 2018 | 283 | Figures 25-26 |
| Oocyte freezing cycles for other medical reasons, 2018 | 26 | Figures 25-26 |
Embryo transfer practice, 2018
| Measure | Value | Source |
|---|---|---|
| Single embryo transfer rate, fresh IVF cycles, 2007 to 2018 | 69.6% to 86.7% | Figure 10a |
| Single embryo transfer rate, freeze cycles, 2018 | 98.2% | Figure 10b |
| Freeze cycles using embryos cultured to day 5-6 (blastocyst), 2018 | 90% | Embryo culture duration section |
Multiple births, 2018
| Measure | Value | Source |
|---|---|---|
| Multiple birth rate per delivery, IVF with own gametes, 2018 (all cycle types) | 2.54% | Table 4 |
| Multiple birth rate per delivery, fresh IVF cycles with own gametes, 2018 | 2.70% | Table 4 |
| Multiple birth rate per delivery, freeze cycles with own gametes, 2018 | 2.37% | Table 4 |
| Multiple pregnancy rate in other countries (context, not Sweden's own figure) | 25%-30% | Multiple pregnancy section |
| Multiple pregnancy rate for spontaneous conception (context, not Sweden's own figure) | about 1% | Multiple pregnancy section |
Complications, fresh IVF cycles, 2018
| Measure | Value | Source |
|---|---|---|
| OHSS cases requiring hospitalization, fresh IVF cycles, 2018 | 42 | Table 3 (complications) |
| OHSS hospitalization rate, fresh IVF cycles, 2018 | 0.38% | Table 3 (complications) |
Patient experience, 2019 survey
| Measure | Value | Source |
|---|---|---|
| Patients rating medical care positively, IVF-KUPP survey | 92% | Figure 29 |
| Patients rating staff approach positively, IVF-KUPP survey | 93% | Figure 29 |
| Patients rating information positively, IVF-KUPP survey | 88% | Figure 29 |
| Patients rating availability positively, IVF-KUPP survey | 84% | Figure 29 |
| Patients rating participation in decision-making positively, IVF-KUPP survey | 74% | Figure 29 |
Our summary of the report's published figures, each citing its table, figure or section. The full report is at the publisher's link.