Q-IVF, & National Quality Registry for Assisted Reproduction (2022). Q-IVF Annual Report 2022: Fertility Treatments in Sweden (Treatment Year 2020). Q-IVF.
Q-IVF, National Quality Registry for Assisted Reproduction. Q-IVF Annual Report 2022: Fertility Treatments in Sweden (Treatment Year 2020). Q-IVF; 2022.
Q-IVF, and National Quality Registry for Assisted Reproduction. Q-IVF Annual Report 2022: Fertility Treatments in Sweden (Treatment Year 2020). Q-IVF, 2022.
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RRM Academy Synopsis
28% of fresh IVF embryo transfers in Sweden in 2020 ended in delivery
About 28 out of 100 fresh IVF embryo transfers ended in a delivery in Sweden in 2020, against 36 out of 100 frozen transfers. The figures come from the national registry's report on cycles with the couple's own eggs and sperm. Delivery per embryo transfer fell with each older age group.
Key Findings
Swedish clinics started 22,868 cycles in 2020, 1,000 fewer than the previous year. The report captures almost 100% of the country's treatments that year.
Per embryo transfer with the couple's own eggs and sperm, delivery rates were 28.1% for fresh cycles and 36.1% for frozen cycles. Of started fresh cycles, 18% ended in a delivery.
Delivery per embryo transfer fell from 38.4% under age 30 to 14.0% at ages 40-41 for fresh cycles, and from 42.3% to 21.1% for frozen cycles.
The cumulative live birth rate per oocyte retrieval, counting all embryo transfers within one year, rose from 28.8% in 2007 to 43.2% in 2019.
Single embryo transfer made up 89% of fresh and 99% of frozen transfers with own gametes in 2020. Twins accounted for 2.82% of 2020 deliveries after fresh cycles and 1.44% after frozen.
Interpretation
The report is the national registry's yearly summary of cycles started in 2020. The design has no randomization and no comparison group of couples who did not undergo IVF. Outcome tables are grouped by cycle type, age group and clinic, with no breakdown by cause of infertility. The registry notes that the number of embryos transferred varies with the patient's prognosis and that clinics treat different types of patients. Confidence intervals are wide for most clinics. The registry traces the higher frozen rates for older women largely to embryos that may have been frozen at a younger age.
RRM Context
Restorative reproductive medicine examines both partners, guided by cycle charting, to find what keeps them from conceiving. Clinicians then treat that cause. IVF bypasses the reproductive system without learning why conception fails. The registry tables show outcomes by cycle type and age, with no breakdown by cause.
Our editorial summary of this paper, not the article's abstract.
Key figures
Treatment volume, 2020
Measure
Value
Source
Total started IVF/ICSI cycles using own gametes, 2020
16 712
Table 1
Fresh-cycle count among started IVF/ICSI cycles, own gametes, 2020
9822
Table 1
Freeze-cycle count among started IVF/ICSI cycles, own gametes, 2020
6890
Table 1
Number of IVF clinics reporting to Q-IVF, 2020
20
Notes from the Head of the Registry
IVF with own gametes, 2020
Measure
Value
Source
Clinical pregnancies from IVF/ICSI, own gametes, 2020
4979
Table 1
Deliveries from IVF/ICSI, own gametes, 2020
4212
Table 1
Live-born children from IVF/ICSI, own gametes, 2020
4270
Table 1
Embryo transfers performed, IVF/ICSI own gametes, 2020
13 125
Table 1
Fresh IVF treatments begun, own gametes, 2020
9819
Figure 7
Live birth rate per started fresh cycle, own gametes, 2020
about 20%
Figure 7
Live birth rate for cycles reaching embryo transfer, fresh, own gametes, 2020
28%
Figure 7
Delivery rate for started fresh IVF/ICSI cycles, own gametes, all ages, 2020
18 percent
Figure 13
Delivery rate for started fresh IVF/ICSI cycles, own gametes, ages 30-35, 2020
23 percent
Figure 13
Delivery rate for started fresh IVF/ICSI cycles, own gametes, age 42 and older, 2020
5 percent
Figure 13
Delivery rate per embryo transfer, fresh IVF/ICSI, own gametes, all ages, 2020
28.1 percent
Figure 14
Delivery rate per embryo transfer, freeze cycles, own gametes, all ages, 2020
36.1 percent
Figure 14
Embryo transfer practice, 2020
Measure
Value
Source
Single-embryo transfer rate, fresh IVF transfers, own gametes, 2012 to 2020
74% to 89%
Figures 10a and 10b
Single-embryo transfer rate, freeze-cycle transfers, own gametes, 2020
99%
Figures 10a and 10b
Multiple births, 2020
Measure
Value
Source
Twin birth rate per delivery, fresh IVF/ICSI, own gametes, 2020
2.82%
Figure 11a
Twin birth rate per delivery, freeze cycles, own gametes, 2020
1.44%
Figure 11a
IVF with donated gametes, 2020
Measure
Value
Source
Delivery rate after fresh transfer, own oocytes with donated sperm, 2020
27%
IVF with donated gametes section
Delivery rate after frozen-thawed transfer, own oocytes with donated sperm, 2020
36%
IVF with donated gametes section
Delivery rate per insemination, donated sperm (IUI-D), all ages, 2020
15.5%
Figure 28
Delivery rate per insemination, donated sperm (IUI-D), women under 30, 2020
20.0%
Figure 28
Share of donated-oocyte transfers done as freeze cycles, 2020
about 90%
IVF with donated oocytes section
Delivery rate per transfer, donated oocytes, freeze cycles, 2019 to 2020
26% to 38%
IVF with donated oocytes section
PGT and fertility preservation, 2020
Measure
Value
Source
Delivery rate per embryo transfer, PGT cycles, 2019 to 2020
33% to 40%
Figure 8
Delivery rate per oocyte retrieval, PGT cycles, 2019 to 2020
24% to 34%
Figure 8
Cumulative live birth
Measure
Value
Source
Cumulative live-birth rate per oocyte retrieval, counting all transfers within a year, 2007 to 2019
28.8% to 43.2%
Figure 21a
Our summary of the report's published figures, each citing its table, figure or section. The full report is at the publisher's link.