Q-IVF, & National Quality Registry for Assisted Reproduction (2023). Q-IVF Annual Report 2023: Fertility Treatments in Sweden (Treatment Year 2021). Q-IVF.
Q-IVF, National Quality Registry for Assisted Reproduction. Q-IVF Annual Report 2023: Fertility Treatments in Sweden (Treatment Year 2021). Q-IVF; 2023.
Q-IVF, and National Quality Registry for Assisted Reproduction. Q-IVF Annual Report 2023: Fertility Treatments in Sweden (Treatment Year 2021). Q-IVF, 2023.
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Sweden's national IVF registry reports that, with the patient's own eggs and sperm, about 27 out of 100 fresh embryo transfers ended in a delivery in 2021, against about 35 out of 100 frozen transfers. The registry's 2023 annual report describes 25,415 treatment cycles started in 2021 at six public and 16 private clinics.
Key Findings
With the patient's own gametes, delivery per embryo transfer across all ages was 26.52% for fresh IVF and 34.67% for freeze cycles.
In fresh IVF cycles, delivery per embryo transfer fell from 37.02% in women under 30 to 6.95% in the oldest age group.
Cumulative live birth rate per oocyte retrieval, counting all embryo transfers within one year, rose from 29.8% in 2007 to 44.6% in 2020.
Single embryo transfer made up 89% of fresh and 99% of freeze-cycle transfers with own gametes in 2021. The percentage of multiple births after IVF decreased from 5.2% to 1.9% since 2007.
Of 11,438 oocyte retrievals in fresh IVF with own or donated gametes, 118 had a reported complication, including 34 cases of ovarian hyperstimulation syndrome requiring hospitalization.
Interpretation
The report summarizes registry data for almost all treatments in Sweden in 2021. The report presents no comparison with couples who did not undergo IVF. Registry counts describe outcomes, and the tables list no infertility diagnosis for the couples treated. The registry's authors note that frozen transfers show higher delivery rates in older women largely because the embryos may have been frozen when the women were younger. They also note that delivery rates after single and double embryo transfer are not directly comparable, because the reason for transferring one or two embryos varies with the patient's prognosis.
RRM Context
Restorative reproductive medicine (RRM) evaluates both partners and treats the underlying cause of reduced fertility, so that conception can occur in the couple's own reproductive system. The registry's background section attributes about one third of fertility problems to the man, about one third to the woman and about one third to both. It describes unexplained infertility as a case where no explanation is found. RRM regards such couples as undiagnosed and continues the evaluation. IVF bypasses the reproductive system without resolving why conception has not occurred.
Our editorial summary of this paper, not the article's abstract.
Key figures
Treatment activity, 2021
Measure
Value
Source
Fresh IVF/ICSI cycles with own gametes, national total
10485
Figure 3
Fresh IVF/ICSI cycles with own gametes, public clinics
3615
Figure 3
Fresh IVF/ICSI cycles with own gametes, private clinics
6870
Figure 3
Freeze cycles with own gametes, national total
7486
Figure 3
Private clinics reporting to the register
16
Notes from the Head of the Registry
Summary, 2021
Measure
Value
Source
Children born nationally as a result of IVF
5283
How we collect data and Notes from the Head of the Registry
Fertility treatments carried out nationally per year
just over 25 000
How we collect data and Notes from the Head of the Registry
IVF outcomes, own gametes, 2021
Measure
Value
Source
Clinical pregnancies from IVF/ICSI with own gametes
5096
Table 1
Embryo transfers performed, IVF/ICSI with own gametes
13965
Table 1
Deliveries from IVF/ICSI with own gametes
4276
Table 1
Live-born children from IVF/ICSI with own gametes
4329
Table 1
Live birth rate per started fresh cycle, own gametes
about 20%
Figure 7
Live birth rate per embryo transfer, fresh IVF own gametes
26%
Figure 7
Delivery rate per embryo transfer, fresh IVF/ICSI own gametes, all ages
26.52 percent
Figure 14
Delivery rate per embryo transfer, freeze cycles own gametes, all ages
34.67 percent
Figure 14
Embryo transfer practice, 2021
Measure
Value
Source
Share of transfers that were single-embryo (SET), fresh IVF, own gametes
89%
Figure 10a
Share of transfers that were single-embryo (SET), freeze cycles, own gametes
99%
Figure 10b
Multiple births, 2021
Measure
Value
Source
Twin birth rate per delivery, fresh IVF/ICSI, own gametes
3.05%
Figure 11a
Twin birth rate per delivery, freeze cycles, own gametes
1.46%
Figure 11a
Trends, 2007-2021
Measure
Value
Source
Multiple birth rate after IVF, national trend
5.2% to 1.9%
Table 3 commentary
Growth in number of deliveries after IVF over 14 years
more than 76%
Table 3 commentary
Donor treatment, IVF, 2021
Measure
Value
Source
Delivery rate per embryo transfer, fresh IVF with donated sperm, all ages
24.6 percent
Figure 22
Delivery rate per embryo transfer, freeze cycles with donated sperm, all ages
36.2 percent
Figure 22
Delivery rate per embryo transfer, fresh IVF/ICSI with donated oocytes, all ages
34.6 percent
Figure 23
Delivery rate per embryo transfer, freeze cycles with donated oocytes, all ages
40 percent
Figure 23
Donor insemination (IUI-D), 2021
Measure
Value
Source
IUI-D started cycles
2214
Table 9
IUI-D deliveries
311
Table 9
IUI-D live births
317
Table 9
Overall delivery rate per insemination, IUI-D
16.3%
Figure 28
Delivery rate per insemination, IUI-D, women under 30
19.0%
Figure 28
PGT treatment, 2021
Measure
Value
Source
PGT started fresh cycles
358
Figure 8
Clinical pregnancies from PGT cycles
108
Figure 8
Deliveries from PGT cycles
94
Figure 8
Our summary of the report's published figures, each citing its table, figure or section. The full report is at the publisher's link.
