RRM Methods

Restorative protocols and outcomes.

100 articles

Understanding Restorative Reproductive Medicine

Boyle P 2025 Open Access Journal of Restorative Reproductive Medicine

Recently, editorials have been published in reproductive medical journals that have misunderstood and misrepresented the origin and meaning of “restorative reproductive medicine” (RRM).1,2 This term w...

Definition and PrinciplesPatient AutonomyRRM vs IVF

Restorative reproductive medicine (RRM) outcomes compared to in-vitro fertilization (IVF) for the treatment of infertility:  a retrospective evaluation of a 2019 clinic cohort compared to one cycle of IVF

Boyle P et al. 2025 Open Access Journal of Restorative Reproductive Medicine

Objectives: Restorative reproductive medicine (RRM) is an emerging approach that can be used to treat infertility. Our goal was to compare RRM to IVF outcomes in 2019. Design: We conducted a retrospec...

RRM vs IVF ComparisonLive Birth RatesPrematurity and Birth Weight

Pregnancies, intentions, and fertility behaviors during use of the Creighton Model FertilityCare System after initial intention to avoid pregnancy: Results from the Creighton Model effectiveness, intentions, behaviors assessment study

Stanford JB et al. 2025 Open Access PloS one

Background: Knowledge of the fertile and infertile phases of the menstrual cycle can be applied to conceive or to avoid pregnancy. Fertility intentions and sexual behaviors during the fertile time may...

Creighton Model SystemProspective CohortIntentions and Compliance

Knowledge of OBGYN Residents of Fertility Awareness Based Methods of Family Planning

Damba-Cunningham E et al. 2025 Open Access Journal of Restorative Reproductive Medicine

Background: Fertility awareness-based methods (FABM) of family planning have increased in popularity in recent years. The effectiveness of various methods can vary substantially and can be user depend...

Residency TrainingPhysician KnowledgeClinical Education

Surgery in Restorative Reproductive Medicine

Yeung P 2025 Open Access Journal of Restorative Reproductive Medicine

Restorative reproductive surgery has emerged to become an exciting and promising field of surgery that can transform the way that we treat patients, especially regarding fertility. As a prime example ...

Excision TechniquesSurgical ManagementFertility Outcomes

Commentary On Infertility and Restorative Reproductive Medicine

Arraztoa JA 2025 Open Access Journal of Restorative Reproductive Medicine

In 1972, a seminal article was published demonstrating that women, adequately trained, could detect the approach of ovulation in the fertile window of their menstrual cycle. It was demonstrated that t...

Foundational PrinciplesClinical ApplicationRestorative Approaches

Welcome to the Journal of Restorative Reproductive Medicine

Stanford JB 2025 Open Access Journal of Restorative Reproductive Medicine

Welcome to the Journal of Restorative Reproductive Medicine, the official journal of the International Institute for Restorative Reproductive Medicine! JRRM is a peer-reviewed, open-access medical jou...

Restorative Reproductive Medicine OverviewDefinition and FrameworkBiomarker-Based Medical Evaluation

Low-Dose Naltrexone as an Adjuvant in Combined Anticancer Therapy

Ciwun M et al. 2024 Open Access Cancers

Naltrexone (NTX) is a non-selective antagonist of opioid receptors, primarily used in the therapy of opioid and alcohol dependence. Low-dose naltrexone (LDN) exhibits antagonistic action against the o...

Low-Dose NaltrexoneLDN ImmunomodulationDrug Repurposing

Successful pregnancy with restorative reproductive medicine after 16 years of infertility, three recurrent miscarriages, and eight unsuccessful embryo transfers with in vitro fertilization/intracytoplasmic sperm injection: a case report

Boyle PC et al. 2022 Open Access Journal of Medical Case Reports

BACKGROUND: Restorative reproductive medicine represents a comprehensive approach to subfertility (infertility and miscarriage) with investigations, diagnoses, and treatments combined with fertility c...

NaProTECHNOLOGYRRM Methods

Naprotechnologia – szansa na potomstwo czy oszustwo?

Kandzia T 2021 Sympozjum

NaProTECHNOLOGY – a chance for offspring or fraud? In the media space in Poland, you can meet the concept of Naprotechnology as an alternative to the in vitro procedure. Often, many myths and untruths...

Effectiveness and EthicsNaProTECHNOLOGYDiagnostic Applications

Is ART utilization the best indicator of access to fertility care?

Stanford JB et al. 2020 Reproductive Biomedicine Online

While we agree with many of the points stated by Dyer et al. in their recent commentary inRBMO(Dyer et al., 2020), we believe their conclusions are focused too narrowly. Limiting the indicator of acce...

Non-ART ApproachesRegistry DevelopmentAlternative Fertility Treatment Frameworks

A Quantitative Self-Assessment of Seminarians' Response to a Curriculum Addition on Marriage, Sexuality, FertilityCare, and Naprotechnology: The Kenrick-Glennon Experience (2006-2015)

Daly KD et al. 2019 The Linacre Quarterly

A special course on Marriage, the Family and Human Sexuality was established at Kenrick-Glennon Seminary in St. Louis so as to assist the seminarians in their better understanding of the Church's teac...

Seminary and Clergy FormationNFP Curriculum OutcomesHumanae Vitae Implementation

The State of the Science of Natural Family Planning Fifty Years after Humane Vitae: A Report from NFP Scientists' Meeting Held at the US Conference of Catholic Bishops, April 4, 2018

Manhart MD et al. 2018 The Linacre Quarterly

A one-day meeting of physicians, professional nurses, and scientists actively involved in Natural Family Planning (NFP) research was held to review the state of the science of NFP and consider future ...

NFP Science State AssessmentModern NFP EffectivenessFuture Research Priorities

Current Medical Research: Summer/Fall 2017

Fehring RJ et al. 2018 The Linacre Quarterly

This issue of Current Medical Research (CMR) includes studies that provide evidence that use of natural family planning (NFP) can be helpful for subfertile couples wishing to achieve a pregnancy, the ...

Quarterly Evidence SummaryNFP Subfertility ApplicationsBreastfeeding Method Effectiveness

Self-Monitoring of Fertility Hormones: A New Era for Natural Family Planning?

Blackwell L et al. 2018 The Linacre Quarterly

Natural family planning (NFP) methods have served many generations well, and in particular, the symptothermal or symptohormonal methods. The comparison of daily mucus and temperature records for indiv...

Home Fertility Hormone MonitoringUrinary Hormone Self-TestingQuantitative Home Immunoassay

Hormonal Predictors of Abnormal Luteal Phases in Normally Cycling Women

Abdulla SH et al. 2018 Open Access Frontiers in Public Health

Objective: Explore potential relationships between preovulatory, periovulatory, and luteal-phase characteristics in normally cycling women. Design: Observational study. Setting: Eight European natural...

Hormonal Predictors of DeficiencyPreovulatory-Luteal Phase RelationshipsCycle Hormone Pattern Analysis

Tamoxifen is Better than Low-Dose Clomiphene or Gonadotropins in Women with Thin Endometrium (<7 mm) after Clomiphene in Intrauterine Insemination Cycles: A Prospective Study

Sharma S et al. 2018 Open Access Journal of Human Reproductive Sciences

Aim: Gonadotropin stimulation is used as the second line of treatment in patients with thin endometrium following clomiphene citrate (CC) administration, which is associated with higher cost, multiple...

Tamoxifen for Thin EndometriumEndometrial Thickness ImprovementClomiphene Alternative Approaches

Achieving Pregnancy Using Primary Care Interventions to Identify the Fertile Window

Bouchard TP et al. 2018 Open Access Frontiers in Medicine

Objective: To determine the effectiveness of achieving pregnancy with focused intercourse in the fertile window identified using natural fertility indicators. Methods: 24-cycle prospective effectiven...

Fertile Window IdentificationPrimary Care Pregnancy AchievementNatural Fertility Indicator Effectiveness

Enrollment, Childbearing Motivations, and Intentions of Couples in the Creighton Model Effectiveness, Intentions, and Behaviors Assessment (CEIBA) Study

Porucznik CA et al. 2017 Open Access Frontiers in Medicine

CONTEXT: The Creighton Model FertilityCare(TM) System (CrM) is a standardized approach for educating women about the biomarkers of their fertility. Couples can use this information for timing intercou...

CEIBA Study Enrollment and MotivationsNFP Couple IntentionsCreighton Model Effectiveness Study

Medical Students' Knowledge of Fertility Awareness-Based Methods of Family Planning

Danis PG et al. 2017 Open Access Frontiers in Medicine

OBJECTIVE: Traditional medical school curricula have not addressed fertility awareness-based methods (FABMs) of family planning. The objective of this study was to assess (1) 3-year medical students' ...

Medical Student FABM Knowledge AssessmentFABM Curriculum GapPhysician Training in Natural Family Planning

Effectiveness of a Natural Family Planning Service Program

Fehring RJ et al. 2016 MCN. The American Journal of Maternal Child Nursing

Purpose: The aims of this study were to determine and compare extended use-effectiveness of an online nurse-managed fertility education service program among women (and subgroups of women) seeking to ...

Electronic Fertility MonitoringTypical and Perfect UseOnline Programs

Couple Beads: An integrated method of natural family planning

Mulcaire-Jones G et al. 2016 The Linacre Quarterly

Various fertility indicators are used by natural family planning methods to identify the fertile and infertile phases of a woman's menstrual cycle: mucus observations, cycle-day probabilities, basal b...

Fertility AwarenessRRM Methods

Impact of Luteal Phase Defect on Ectopic Pregnancy Risk

Miller B et al. 2015 ** NOT_FOUND

Introduction: Luteal phase deficiency (LPD), while commonly observed and managed in stimulated in-vitro fertilisation cycles, is a more contentious phenomenon in natural cycles. The challenge arises i...

Clinical OutcomesDeficiencyOvulatory Dysfunction

Influence of motivation on the efficacy of natural family planning

Fehring RJ et al. 2013 MCN. The American Journal of Maternal Child Nursing

Purpose: To determine the influence of mutual motivation on unintended pregnancy rates of couples who used natural family planning (NFP) methods to avoid pregnancy. STUDY DESIGN AND Methods: Using an...

Motivation FactorsUser ComplianceBehavioral Methods

Current practice in tubal surgery and adhesion management: a review

Watrelot A et al. 2011 Reproductive Biomedicine Online

The diminished role of tubal surgery in infertile women following widespread access to IVF is now being reviewed as more patients and surgeons today consider tubal surgery as an effective alternative ...

Techniques and OutcomesSurgical TreatmentTubal Reconstruction

Efficacy and Efficiency in Natural Family Planning Services

Fehring RJ 2009 The Linacre Quarterly

Relatively few Catholic couples in the United States use modern methods of natural family planning (NFP). So too, few Catholic physicians and health professionals prescribe the use of NFP methods for ...

NFP Efficacy and EffectivenessCatholic Healthcare IntegrationBarriers and Adoption

Efficacy of the Marquette Method of natural family planning

Fehring RJ et al. 2008 MCN. The American Journal of Maternal Child Nursing

Purpose: To determine the effectiveness of the Marquette Method (MM) of natural family planning (NFP) as a method of avoiding pregnancy. STUDY DESIGN AND Methods: This was a 12-month retrospective ev...

Marquette MethodPregnancy Avoidance RatesElectronic Hormonal Monitoring

New low- and high-tech calendar methods of family planning

Fehring RJ 2005 Journal of Midwifery & Women's Health

Calendar-based methods are not usually considered effective or useful methods of family planning among health professionals. However, new "high-" and "low"-tech calendar methods have been developed, w...

Calendar-Based MethodsHormonal MonitoringFertile Window Algorithms

The future of professional education in natural family planning

Fehring RJ 2004 Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN

Nurses and other health care professionals often have little knowledge of methods of natural family planning (NFP) and do not readily prescribe natural methods for their patients. One reason for this ...

Professional Training ProgramsHealthcare Provider EducationDistance Education

Prophylactic administration of progesterone by vaginal suppository to reduce the incidence of spontaneous preterm birth in women at increased risk: a randomized placebo-controlled double-blind study

da Fonseca EB et al. 2003 American Journal of Obstetrics and Gynecology

OBJECTIVE: The purpose of this study was to evaluate the effect of prophylactic vaginal progesterone in decreasing preterm birth rate in a high-risk population. STUDY DESIGN: A randomized, double-bli...

Progesterone ProphylaxisPreterm Birth PreventionPregnancy Interventions

Infertility is a symptom, not a disease

Dickey RP et al. 2000 Fertility and Sterility

In an otherwise excellent editorial that appeared in this journal concerning the problems created by failure of the Health Insurance Industry to provide coverage for infertility, the author, a noted a...

Underlying Disease IdentificationInfertility as SymptomRoot Cause Diagnosis of Infertility

Plasma concentrations of progesterone are higher in the uterine artery than in the radial artery after vaginal administration of micronized progesterone in an oil-based solution to postmenopausal women

Cicinelli E et al. 1998 Fertility and Sterility

OBJECTIVE: To verify the occurrence of preferential distribution of vaginally administered progesterone to the uterus compared with extrapelvic regions in vivo and in humans. DESIGN: Prospective clin...

Vaginal Administration PharmacokineticsProgesterone SupplementationProgesterone Delivery Routes

Expanding the availability and improving delivery of natural family planning services and fertility awareness education: providers' perspectives

Arévalo M 1997 Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception

Despite the recognized benefits for clients and programs of providing natural family planning (NFP) services, few family planning programs offer NFP and few provide fertility awareness education. Furt...

Provider Perspectives and BarriersNFP in Family PlanningNFP Service Expansion

Simplifying NFP: preliminary report of a pilot study of the 'collar' method in Brazil

Faundes A et al. 1997 Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception

Natural methods of fertility regulation are acceptable in most cultures. Many couples worldwide do not wish to use contraceptives or do not have access to them but wish to limit their family size or l...

Calendar-Based MethodsPilot StudiesStandard Days Method

Natural family planning. Natural methods have cross cultural appeal

Billings JJ 1993 BMJ (Clinical Research Ed.)

good of all, and above all, for the protection of the weak."2I submit that, no matter how appealing a marketplace model may seem for the NHS, it is a business model.As such the destruction of either p...

Fertility AwarenessRRM Methods

Evaluation of natural family planning programmes in Liberia and Zambia

Gray RH et al. 1993 Journal of Biosocial Science

Studies to evaluate use-effectiveness and cost-effectiveness of natural family planning (NFP) were conducted in Liberia and Zambia. The Liberian programme provided uni-purpose NFP services to 1055 cli...

Developing CountriesUse-Effectiveness RatesCost-Effectiveness

Absorption of micronized progesterone from a nonliquefying vaginal cream

Kimzey LM et al. 1991 Fertility and Sterility

An improved delivery method to achieve sustained physiological P levels would be useful. Based on this single-dose pharmacokinetic study, micronized P prepared in a nonliquefying vaginal cream holds p...

Vaginal AdministrationDelivery MethodsHormone Delivery

Physicians' views of periodic abstinence methods: a study in four countries

Snowden R et al. 1988 Studies in Family Planning

A study of the knowledge, perceptions, and behavioral intentions of physicians regarding periodic abstinence (PA) methods was undertaken in Mauritius, Peru, the Philippines, and Sri Lanka. Most respon...

Physician Knowledge and AttitudesHealthcare Provider PerspectivesFamily Planning Counseling

Urinary follicle stimulating hormone treatment for luteal phase defect

Minassian SS et al. 1988 The Journal of Reproductive Medicine

A deficiency in follicle stimulating hormone (FSH) levels during the early follicular phase of the menstrual cycle has been shown to result in luteal phase defect (LPD). A short course of human urinar...

Gonadotropin TherapyLuteal Phase DefectFSH Supplementation

Bioavailability of progesterone with different modes of administration

Chakmakjian ZH et al. 1987 The Journal of Reproductive Medicine

The bioavailability of micronized progesterone (P) was studied by measuring sequential serum P concentrations after a single bolus of 50-200 mg P given sublingually, orally (capsule and tablet), vagin...

Bioavailability Routes of AdministrationPharmacokineticsMicronized Progesterone

Professional Program Development in Natural Family Planning

Hilgers TW 1986 The Linacre Quarterly

There is no information available about the effect of iron in formula on the development of gastrointestinal humoral immune response in early human infancy. We compared standard Enfamil to iron-fortif...

Professional TrainingNFP EducationService Development

Pregnancies following chronic intermittent (pulsatile) administration of Gn-RH by means of a portable pump ("Zyklomat")--a new approach to the treatment of infertility in hypothalamic amenorrhea

Leyendecker G et al. 1980 The Journal of Clinical Endocrinology and Metabolism

In previous studies it could be demonstrated that in severe hypothalamic amenorrhea, which is associated with absent or deficient hypothalamic secretion of Gn-RH, ovarian function could be restored by...

Pulsatile GnRH TherapyAmenorrhea TreatmentGnRH Replacement

Natural family planning

Lanctôt CA 1979 Clinics in Obstetrics and Gynaecology

NFP (natural family planning) has replaced the term of rhythm method in the last decade as a designation for those methods of fertility regulation based on periodic abstinence. A graph presents the sy...

NFP EffectivenessCounseling ProgramsMethod Comparison

The ovulation method of natural family planning

Hume K 1977 Irish Medical Journal

The ovulation method of natural family planning is described in detail as taught in the ovulation method centers with an account of its development in Australia and the underlying philosophy. Hormonal...

Ovulation Method (Billings)Hormonal CorrelationEffectiveness Studies