Frank-Herrmann P et al.2026Fertility and sterility
Peipert et al. (1) claim that restorative reproductive medicine (RRM) originated as a political and religious movement with the purpose to limit access to in vitro fertilization (IVF). In so doing, th...
Sánchez-Méndez JI et al.2025
Open Access
Frontiers in reproductive health
Introduction: Assisted reproductive technologies (ART) are widely used to address infertility; however, they are costly, associated with medical risks, and often yield suboptimal clinical outcomes. Na...
Boyle P2025
Open Access
Journal of Restorative Reproductive Medicine
Recently, editorials have been published in reproductive medical journals that have misunderstood and misrepresented the origin and meaning of “restorative reproductive medicine” (RRM).1,2 This term w...
Definition and PrinciplesPatient AutonomyRRM vs IVF
Boyle P et al.2025
Open Access
Journal of Restorative Reproductive Medicine
Objectives: Restorative reproductive medicine (RRM) is an emerging approach that can be used to treat infertility. Our goal was to compare RRM to IVF outcomes in 2019.
Design: We conducted a retrospec...
RRM vs IVF ComparisonLive Birth RatesPrematurity and Birth Weight
Background: Knowledge of the fertile and infertile phases of the menstrual cycle can be applied to conceive or to avoid pregnancy. Fertility intentions and sexual behaviors during the fertile time may...
Creighton Model SystemProspective CohortIntentions and Compliance
A one-day meeting was held as a pre-conference to the Catholic Medical Association Annual Educational event in 2024. A panel of eighteen physicians, scientists, and researchers involved in NFP work wa...
Evidence ReviewHormone Monitoring and AppsPostpartum and Perimenopause
Bulletti FM et al.2025
Open Access
Therapeutic advances in reproductive health
Background: Infertility affects around 17.5% of reproductive-aged individuals worldwide, posing significant personal and public health challenges. Although Medically Assisted Reproduction and Assisted...
Integrated Treatment ModelsRestorative vs ARTLaparoscopy and Hysteroscopy
Damba-Cunningham E et al.2025
Open Access
Journal of Restorative Reproductive Medicine
Background: Fertility awareness-based methods (FABM) of family planning have increased in popularity in recent years. The effectiveness of various methods can vary substantially and can be user depend...
Background Reproductive hormones of the fertile window are often referenced to women in regular cycles, but this may not be representative of the hormonal profiles of women in different circumstances ...
Yeung P2025
Open Access
Journal of Restorative Reproductive Medicine
Restorative reproductive surgery has emerged to become an exciting and promising field of surgery that can transform the way that we treat patients, especially regarding fertility. As a prime example ...
Arraztoa JA2025
Open Access
Journal of Restorative Reproductive Medicine
In 1972, a seminal article was published demonstrating that women, adequately trained, could detect the approach of ovulation in the fertile window of their menstrual cycle. It was demonstrated that t...
Stanford JB2025
Open Access
Journal of Restorative Reproductive Medicine
Welcome to the Journal of Restorative Reproductive Medicine, the official journal of the International Institute for Restorative Reproductive Medicine! JRRM is a peer-reviewed, open-access medical jou...
Restorative Reproductive Medicine OverviewDefinition and FrameworkBiomarker-Based Medical Evaluation
Malcom CA et al.2025Journal of assisted reproduction and genetics
PURPOSE: Prior studies in fresh embryo transfer IVF cycles have associated elevated serum progesterone level on day of ovulatory trigger, particularly if ≥ 1.5 ng/ml, with decreased pregnancy rates. A...
Fertility awareness-based methods (FABMs), also known as natural family planning (NFP), enable couples to identify the days of the menstrual cycle when intercourse may result in pregnancy ("fertile da...
BACKGROUND AND Objectives: Fertility awareness-based methods (FABMs) are evidence-based means of tracking observable biomarkers of a woman's fertility for the purpose of reproductive health monitoring...
Medical TrainingCurriculum DevelopmentFABM Knowledge
Naltrexone (NTX) is a non-selective antagonist of opioid receptors, primarily used in the therapy of opioid and alcohol dependence. Low-dose naltrexone (LDN) exhibits antagonistic action against the o...
Meyers M et al.2023
Open Access
Medicina (Kaunas, Lithuania)
The fertility tracking of menstrual cycles during perimenopause with a quantitative hormone monitor is a novel undertaking. Women in regular menstrual cycles have been tracking their fertility using d...
Background
Natural Procreative Technology (NaProTechnology) is a system of management of infertility and other reproductive health issues which requires the application of a woman’s observation and re...
For years, reproductive surgery was the mainstay of reproductive care. With the evolution and ultimate success of in vitro fertilization (IVF), reproductive surgery became an adjuvant therapy, indicat...
Modern Role and EvolutionSurgical vs ARTFertility Preservation
BACKGROUND AND Objectives: Knowledge and competency in the topics of reproductive health and family planning are important for primary care physicians. Given the high rates of unintended pregnancy, in...
Medical School CurriculaPhysician TrainingMedical Education Gaps
Neblett MF 2nd et al.2023Journal of assisted reproduction and genetics
PURPOSE: To assess efficacy of adjuvant dexamethasone during letrozole cycles for ovulation induction (OI) in women with letrozole-resistant polycystic ovary syndrome (PCOS).
METHODS: We retrospectiv...
Stanford JB et al.2022
Open Access
Human Reproduction Open
STUDY QUESTION: What is the feasibility of a prospective protocol to follow subfertile couples being treated with natural procreative technology for up to 3 years at multiple clinical sites?
SUMMARY ...
Boyle PC et al.2022
Open Access
Journal of Medical Case Reports
BACKGROUND: Restorative reproductive medicine represents a comprehensive approach to subfertility (infertility and miscarriage) with investigations, diagnoses, and treatments combined with fertility c...
Women of reproductive age need reliable and effective family planning methods to manage their fertility. Natural family planning (NFP) methods or fertility awareness-based methods (FABMs) have been in...
Shirin S et al.2021
Open Access
Medicina (Kaunas, Lithuania)
Background and Objectives: Women with androgenic Polycystic Ovary Syndrome (PCOS) have increased endometrial cancer risk that cyclic progesterone will prevent; it may also reverse PCOS's neuroendocrin...
Stanford JB et al.2021
Open Access
BMC Pregnancy and Childbirth
Background: Restorative reproductive medicine (RRM) seeks to identify and correct underlying causes and factors contributing to infertility and reproductive dysfunction. Many components of RRM are hig...
NaProTECHNOLOGY – a chance for offspring or fraud? In the media space in Poland, you can meet the concept of Naprotechnology as an alternative to the in vitro procedure. Often, many myths and untruths...
Effectiveness and EthicsNaProTECHNOLOGYDiagnostic Applications
Stanford JB et al.2020Reproductive Biomedicine Online
While we agree with many of the points stated by Dyer et al. in their recent commentary inRBMO(Dyer et al., 2020), we believe their conclusions are focused too narrowly. Limiting the indicator of acce...
One aspect of the progressive secularization of biotechnology is the use of the by-products from abortion and the use of human embryos. These morally illicit cells and tissue create a significant mora...
Mirkes R2020The National Catholic Bioethics Quarterly
This article considers one question: How does the Catholic Church guide infertile couples to exercise their right to build a family? Part One examines the principal tenets of Catholic social teaching ...
A special course on Marriage, the Family and Human Sexuality was established at Kenrick-Glennon Seminary in St. Louis so as to assist the seminarians in their better understanding of the Church's teac...
Seminary and Clergy FormationNFP Curriculum OutcomesHumanae Vitae Implementation
Identifying the return of fertility with cervical mucus observations is challenging during the postpartum period. Use of urinary measurements of estrogen and progesterone can assist in understanding t...
A one-day meeting of physicians, professional nurses, and scientists actively involved in Natural Family Planning (NFP) research was held to review the state of the science of NFP and consider future ...
NFP Science State AssessmentModern NFP EffectivenessFuture Research Priorities
Boyle PC et al.2018
Open Access
Frontiers in Medicine
Objectives: To determine the live birth rate for patients who chose to undergo treatment with Restorative Reproductive Medicine (RRM) after previous IVF (includes ICSI). To look at birth outcomes with...
Post-IVF RRM TreatmentLive Birth RatesRRM vs IVF Outcomes
This issue of Current Medical Research (CMR) includes studies that provide evidence that use of natural family planning (NFP) can be helpful for subfertile couples wishing to achieve a pregnancy, the ...
Natural family planning (NFP) methods have served many generations well, and in particular, the symptothermal or symptohormonal methods. The comparison of daily mucus and temperature records for indiv...
Home Fertility Hormone MonitoringUrinary Hormone Self-TestingQuantitative Home Immunoassay
Sharma S et al.2018
Open Access
Journal of Human Reproductive Sciences
Aim: Gonadotropin stimulation is used as the second line of treatment in patients with thin endometrium following clomiphene citrate (CC) administration, which is associated with higher cost, multiple...
Tamoxifen for Thin EndometriumEndometrial Thickness ImprovementClomiphene Alternative Approaches
Bouchard TP et al.2018
Open Access
Frontiers in Medicine
Objective: To determine the effectiveness of achieving pregnancy with focused intercourse in the fertile window identified using natural fertility indicators.
Methods: 24-cycle prospective effectiven...
Fertile Window IdentificationPrimary Care Pregnancy AchievementNatural Fertility Indicator Effectiveness
Porucznik CA et al.2017
Open Access
Frontiers in Medicine
CONTEXT: The Creighton Model FertilityCare(TM) System (CrM) is a standardized approach for educating women about the biomarkers of their fertility. Couples can use this information for timing intercou...
CEIBA Study Enrollment and MotivationsNFP Couple IntentionsCreighton Model Effectiveness Study
Danis PG et al.2017
Open Access
Frontiers in Medicine
OBJECTIVE: Traditional medical school curricula have not addressed fertility awareness-based methods (FABMs) of family planning. The objective of this study was to assess (1) 3-year medical students' ...
Medical Student FABM Knowledge AssessmentFABM Curriculum GapPhysician Training in Natural Family Planning
Frank-Herrmann P et al.2017Archives of Gynecology and Obstetrics
Purpose: To analyze cumulative pregnancy rates of subfertile couples after fertility awareness training.
Methods: A prospective observational cohort study followed 187 subfertile women, who had recei...
The topic of how the menstrual cycle is a vital sign which could signal pathophysiologic process has received considerable attention in the past decade. The current recommendations of various academic...
Fehring RJ et al.2016MCN. The American Journal of Maternal Child Nursing
Purpose: The aims of this study were to determine and compare extended use-effectiveness of an online nurse-managed fertility education service program among women (and subgroups of women) seeking to ...
Electronic Fertility MonitoringTypical and Perfect UseOnline Programs
Various fertility indicators are used by natural family planning methods to identify the fertile and infertile phases of a woman's menstrual cycle: mucus observations, cycle-day probabilities, basal b...
Fehring RJ et al.2015Journal of Midwifery & Women's Health
Introduction: The length of periodic abstinence, due to overestimation of the fertile phase of the menstrual cycle, is often a cause for dissatisfaction, discontinuation, and user error with natural f...
Monitor vs MucusEstimation AccuracyFertility Monitor Protocol
American Society for Reproductive Medicine2015Fertility and Sterility
This document reviews surgical options for achieving patency in obstructed fallopian tubes and the factors that must be considered when deciding between surgical repair and IVF. This document replaces...
Tubal Repair vs IVFTreatment OptionsFallopian Tube Restoration
Introduction: Luteal phase deficiency (LPD), while commonly observed and managed in stimulated in-vitro fertilisation cycles, is a more contentious phenomenon in natural cycles. The challenge arises i...
Fehring RJ et al.2013MCN. The American Journal of Maternal Child Nursing
Purpose: To determine the influence of mutual motivation on unintended pregnancy rates of couples who used natural family planning (NFP) methods to avoid pregnancy. STUDY DESIGN AND
Methods: Using an...
Kelly PJ et al.2012Journal of Midwifery & Women's Health
INTRODUCTION: Natural family planning (NFP) methods are effective for contraception with proper and consistent use. However, only 1% of patients at federally funded Title X family planning clinics sel...
Clinician Training and PerspectivesTitle X Clinic ImplementationProvider Barriers and Facilitators
Watrelot A et al.2011Reproductive Biomedicine Online
The diminished role of tubal surgery in infertile women following widespread access to IVF is now being reviewed as more patients and surgeons today consider tubal surgery as an effective alternative ...
Techniques and OutcomesSurgical TreatmentTubal Reconstruction
Fehring RJ et al.2011Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN
Objective: To evaluate the efficacy, knowledge of fertility, and acceptability of a web-based natural family planning (NFP) education and service program.
Design: A 6-month repeated measure longitudin...
Boyle PC et al.2011Biomedicina (Sveikatos Mokslai/Health Sciences)
Description: Infertility is usually a consequence of multiple chronic conditions rather than a single acute condition. We propose that it is erroneous to apply acute medical interventions to a conditi...
Relatively few Catholic couples in the United States use modern methods of natural family planning (NFP). So too, few Catholic physicians and health professionals prescribe the use of NFP methods for ...
NFP Efficacy and EffectivenessCatholic Healthcare IntegrationBarriers and Adoption
Fehring RJ et al.2008MCN. The American Journal of Maternal Child Nursing
Purpose: To determine the effectiveness of the Marquette Method (MM) of natural family planning (NFP) as a method of avoiding pregnancy. STUDY DESIGN AND
Methods: This was a 12-month retrospective ev...
Fehring RJ2005Journal of Midwifery & Women's Health
Calendar-based methods are not usually considered effective or useful methods of family planning among health professionals. However, new "high-" and "low"-tech calendar methods have been developed, w...
Fehring RJ2004Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN
Nurses and other health care professionals often have little knowledge of methods of natural family planning (NFP) and do not readily prescribe natural methods for their patients. One reason for this ...
Professional Training ProgramsHealthcare Provider EducationDistance Education
da Fonseca EB et al.2003American Journal of Obstetrics and Gynecology
OBJECTIVE: The purpose of this study was to evaluate the effect of prophylactic vaginal progesterone in decreasing preterm birth rate in a high-risk population.
STUDY DESIGN: A randomized, double-bli...
In an otherwise excellent editorial that appeared in this journal concerning the problems created by failure of the Health Insurance Industry to provide coverage for infertility, the author, a noted a...
Underlying Disease IdentificationInfertility as SymptomRoot Cause Diagnosis of Infertility
de Leizaola MA1998Journal De Gynecologie, Obstetrique Et Biologie De La Reproduction
A Belgian pilot-study conducted in the framework of the prospective European multi-center study (University of Düsseldorf) tried to establish the use-effectiveness (a sine qua non condition for its ac...
OBJECTIVE: To verify the occurrence of preferential distribution of vaginally administered progesterone to the uterus compared with extrapelvic regions in vivo and in humans.
DESIGN: Prospective clin...
Roozenburg BJ et al.1997Human Reproduction (Oxford, England)
Patients suffering from normogonadotrophic anovulation and infertility are initially treated with clomiphene citrate. Those who do not respond to clomiphene citrate usually receive gonadotrophin treat...
Arévalo M1997Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception
Despite the recognized benefits for clients and programs of providing natural family planning (NFP) services, few family planning programs offer NFP and few provide fertility awareness education. Furt...
Provider Perspectives and BarriersNFP in Family PlanningNFP Service Expansion
Faundes A et al.1997Advances in Contraception : the Official Journal of the Society for the Advancement of Contraception
Natural methods of fertility regulation are acceptable in most cultures. Many couples worldwide do not wish to use contraceptives or do not have access to them but wish to limit their family size or l...
Calendar-Based MethodsPilot StudiesStandard Days Method
Objective: To evaluate whether the efficacy of naltrexone administration in patients with hypothalamic amenorrhea correlates to the response to an acute naloxone test.
Design: Thirty patients with hyp...
Hypothalamic Amenorrhea TreatmentOpioid Antagonist TherapyNaltrexone for Amenorrhea
Frishman GN et al.1995The Journal of Reproductive Medicine
OBJECTIVE: Vaginal progesterone suppositories are an accepted treatment for infertility attributed to luteal phase defects. Although oral micronized progesterone may be preferable to suppositories for...
good of all, and above all, for the protection of the weak."2I submit that, no matter how appealing a marketplace model may seem for the NHS, it is a business model.As such the destruction of either p...
Studies to evaluate use-effectiveness and cost-effectiveness of natural family planning (NFP) were conducted in Liberia and Zambia. The Liberian programme provided uni-purpose NFP services to 1055 cli...
An improved delivery method to achieve sustained physiological P levels would be useful. Based on this single-dose pharmacokinetic study, micronized P prepared in a nonliquefying vaginal cream holds p...
A study of the knowledge, perceptions, and behavioral intentions of physicians regarding periodic abstinence (PA) methods was undertaken in Mauritius, Peru, the Philippines, and Sri Lanka. Most respon...
Physician Knowledge and AttitudesHealthcare Provider PerspectivesFamily Planning Counseling
Minassian SS et al.1988The Journal of Reproductive Medicine
A deficiency in follicle stimulating hormone (FSH) levels during the early follicular phase of the menstrual cycle has been shown to result in luteal phase defect (LPD). A short course of human urinar...
Chakmakjian ZH et al.1987The Journal of Reproductive Medicine
The bioavailability of micronized progesterone (P) was studied by measuring sequential serum P concentrations after a single bolus of 50-200 mg P given sublingually, orally (capsule and tablet), vagin...
Bioavailability Routes of AdministrationPharmacokineticsMicronized Progesterone
Check JH et al.1987International Journal of Fertility
A study was designed to see if the use of prophylactic progesterone vaginal suppositories (PVS) reduced the risk of spontaneous abortions in women with a history of at least one spontaneous abortion. ...
There is no information available about the effect of iron in formula on the development of gastrointestinal humoral immune response in early human infancy. We compared standard Enfamil to iron-fortif...
Professional TrainingNFP EducationService Development
Leyendecker G et al.1980The Journal of Clinical Endocrinology and Metabolism
In previous studies it could be demonstrated that in severe hypothalamic amenorrhea, which is associated with absent or deficient hypothalamic secretion of Gn-RH, ovarian function could be restored by...
Lanctôt CA1979Clinics in Obstetrics and Gynaecology
NFP (natural family planning) has replaced the term of rhythm method in the last decade as a designation for those methods of fertility regulation based on periodic abstinence. A graph presents the sy...
The ovulation method of natural family planning is described in detail as taught in the ovulation method centers with an account of its development in Australia and the underlying philosophy. Hormonal...